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Six days a week, middle-aged industrial millionaire John Cleves leaves his New York City office and returns home to his wife, Dorothy, in New Jersey. On Wednesdays, when he is supposedly away on business trips, he goes to the East Side apartment of his young mistress, Ellen Gordon. Because the apartment is listed in John's expense books as an "executive suite," his new and inexperienced secretary gives the address to Cass Henderson, an out-of-town businessman who can't find a hotel room. Upon discovering Ellen in the apartment, Cass concludes she is a party girl supplied by Cleves. The situation becomes even stickier when the secretary next gives the address to Mrs. Cleves, who arrives at the apartment and assumes that Ellen and Cass are married. Delighted to meet a young couple from Ohio, Dorothy insists that the Hendersons join the Cleves for a night on the town. The evening is a disaster for all concerned, culminating in the breakup of the Cleves' marriage. Although John moves into Ellen's apartment, Ellen becomes friends with Dorothy and offers her the use of the "executive suite" whenever she is in town. As a result, John arrives there one day and discovers his as yet undivorced wife taking a bath. Ellen also bursts in, catches them making love, and, furious, races into the arms of the delighted Cass. John then begs Dorothy to take him back. After consideration, she decides he is very poor husband material; but she assures him that he can call her "any Wednesday."