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The film's title card reads "Jacqueline Susann's The Love Machine." According to a June 1969 news item in Publishers Weekly, producer M. J. "Mike" Frankovich bought the rights to Susann's book for a base payment of $1,500,000 against 10% of the film's gross, a record at the time. A May 1969 Hollywood Reporter news item added that as part of the deal, Susann's husband, Irving Mansfield, was given the title of executive producer. SuJac Productions was owned by Susann and Mansfield.
According to Filmfacts, Brian Kelly was originally cast as "Robin Stone," but was replaced by John Phillip Law after Kelly was seriously injured in a motorcycle accident. According to a July 1970 news item in Beverly Hills Citizen News, the following actors were considered for the role of Stone: Robert Wagner, Rick Jason, Robert Fuller, Robert Brown, Eric Braeden, Stephen Boyd and Warren Beatty. Filmfacts also noted that many of the scenes featuring Sharon Farrell as "Maggie Stewart" were cut from the released film.
Publicity materials in the film's production file at the AMPAS Library noted that location filming in California was shot at the Beverly Hills Police Department, the Hotel Bel-Air and television station KTTV in Los Angeles. New York City location filming was done at the East River Docks, Sutton Place, Danny's Hideaway and at the United Nations Building. Although the onscreen credits read "introducing Jodi Wexler," The Love Machine was Wexler's only film.
August 1971 Hollywood Reporter items noted that the Writers Guild sought and won an injunction against Columbia Pictures barring any advertising in which screenwriter Samuel Taylor was not given proper credit. Modern sources add Melonie Haller and Linda Morand to the cast. Several well-known celebrities appeared in cameos in the film, among them boxer Sugar Ray Robinson, comedian Don Rickles and local Los Angeles newscaster Jerry Dunphy.