- Co-writer Chris Miller (III) based the National Lampoon short stories that gave rise to the film on his experiences in the Alpha Delta Phi fraternity at Dartmouth (from which he graduated in 1962).
- The movie was set to be filmed at the University of Missouri until the president of the school read the script and refused permission. It was filmed at and around the University of Oregon in Eugene instead.
- The Delta House actors were brought to the set 5 days before the Omega House actors to get into character, in an intentional effort to cause cliques to form.
- The movie concludes by describing each character's fate. Niedermeyer was "killed in Vietnam by his own troops." In director John Landis' segment of Twilight Zone: The Movie (1983), some soldiers are overheard discussing "fragging Niedermeyer."
- The bass player in the band Otis Day and the Knights is then-unknown bluesman Robert Cray. Cray was instrumental in getting the musicians together that appeared as the band.
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