Two Westerners investigate a double murder blamed on renegades.

In frontier Arizona, Old Surehand, a self-appointed lawman and blood brother of the young Apache chief Winnetou, is the sworn enemy of the Vultures, a band of outlaws disguised as Indians who terrorize prospectors and settlers. When the Vultures capture Annie, who is transporting her father's moneybelt filled with diamonds, Martin Baumann, who is in love with Annie, rescues her. Baumann mistakenly believes that the Shoshone are responsible for the slaughter of his family, and he is captured by the tribe for insulting their chief, but Old Surehand saves Baumann's life by performing feats of skill and strength. Old Surehand, Winnetou, and Baumann then hear that the wagon train in which Annie is traveling is about to be ambushed by the Vultures, and they fight off the gang until the Shoshone come to the rescue.