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According to a September 1947 Hollywood Reporter news item, M-G-M paid $200,000 for the film rights to Marcia Davenport's novel. An August 1948 Los Angeles Times news item noted that Greer Garson was considered for a starring role. According to a June 1949 Hollywood Reporter news item, M-G-M negotiated with Fred MacMurray and Claudette Colbert to play the leading roles. A contemporary news items list Arlene Dahl and Mary Astor in the cast, but they did not appear in the released film. While early Hollywood Reporter production charts list actor Reginald Gardner in the cast, he was not in the film and it is possible that his name was confused with Ava Gardner's, whose name replaced his in all charts from August 12, 1949 on. Contemporary sources indicate that some background footage used was shot in New York City for the film.
East Side, West Side marked actress Gale Sondergaard's last film for twenty years. Sondergaard, along with her husband, producer-director Herbert Biberman, was blacklisted following hearings of the House Committee on Un-American Activities. For additional information, please see entry above for Crossfire.