- Two Mustangs and two Dodge Chargers were used for the famous chase scene. Both Mustangs were owned by the Ford Motor Company and part of a promotional loan agreement with Warner Brothers. The cars were modified for the high-speed chase by veteran auto racer Max Balchowsky. Stunt coordinator Carey Loftin got Bud Ekins to drive the Mustang for the bulk of the stunts. Both of the Dodges were junked after the filming, as was one of the Mustangs. The other less banged-up Mustang was purchased by a WB employee after all production and post-production was completed. The car ended up in New Jersey a few years later, where Steve McQueen attempted to buy it. The owner refused to sell, and the car now sits in a barn and has not been driven in many years.
- The director called for speeds of about 75-80 mph, but the cars (including the ones containing the cameras) reached speeds of over 110 mph. Filming of the chase scene took three weeks, resulting in 9 minutes and 42 seconds of footage. They were denied permission to film on the Golden Gate Bridge.
- The Mustang's interior mirror goes up and down depending who is driving it - Steve McQueen (up, visible) or Bud Ekins (down, not visible).
- This film is edited entirely by cuts except in two instances. The first occurs when the jazz club scene dissolves to a shot of Steve McQueen lying in bed. The second occurs after the Dodge crashes into the gas station and burns, when the shot of the two dead villains dissolves to a scene at the police station.
- This was the first mainstream Hollywood film to use the expletive "Bullshit!" in its script.
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