- Edward G. Robinson was the original choice for the role of Dr. Zaius, and actually filmed a test scene with Charlton Heston to prove to the executives at Fox that make-up could be used to create believable simians. However, Robinson suffered from a weak heart and didn't think he could endure the day-to-day rigors of performing in the ape make-up. He and Heston had previously teamed up in The Ten Commandments (1956) and would do so again in Soylent Green (1973).
- During breaks in filming, actors made up as different ape species tended to hang out together--- gorillas with gorillas, orangutans with orangutans, chimps with chimps. It wasn't required, it just naturally happened.
- There is a resort in Cabo San Lucas, Mexico that claims that final scene ("Damn you!") was filmed on their beach. This is not true. According to a recent documentary, the scene was filmed on Zuma Beach in Southern California.
- In the novel, the apes are technologically very advanced. However, the budget could not accommodate the visual scope and magnitude of such a futuristic society, so a more primitive depiction of ape society was used.
- Although Charlton Heston's character is listed in the credits as 'George Taylor', the name 'George' is never seen or heard in the film. He is referred to only as 'Taylor'.
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