- Whenever Fernando Rey is speaking French in the film, his voice is dubbed by a French actor.
- Alain Charnier's villa is the same building used in the original film, French Connection, The (1971).
- In planning the climactic chase in which Doyle pursues Charnier across Marseilles, director John Frankenheimer wasn't aware that Gene Hackman suffered from knee problems. Despite this, Hackman went ahead and filmed the entire chase without a double, badly inflaming his knee by the time he was through. He has said that Doyle's expressions of pain and determination as the chase progressed didn't require much acting.
- Doyle's memorable cry of "Mickey Mantle sucks!" during the cold turkey sequence was the source of much trouble for the film makers and their legal department. Producer Robert L. Rosen had to track down Mickey Mantle to obtain his permission for the reference. After a long phone call, Rosen flew out to Mantle's home in Dallas with a print of the film, which was screened for him and his lawyer. When Hackman uttered the line, Mantle surprised Rosen not only by roaring with laughter but also insisting that they watched the rest of the film because both he and his lawyer were enjoying it so much. Mantle later happily signed a release waiver and the line stayed in the film.
- Eddie Egan, the real-life New York cop who was the basis for the character of Jimmy Doyle in "The French Connection", really did have a try-out for the Yankees in his youth, and played alongside a then-unknown Mickey Mantle.
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