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According to news items in Hollywood Reporter, George Raft was originally slated to play the part of John Gamble, but he objected to the story and turned down the role. Warner Bros. decided to replace him with Dennis Morgan, but when RKO objected because Warner Bros. had previously agreed to lend Morgan to them for Kitty Foyle, Warner Bros. suspended Raft and temporarily shelved South of Suez. The production was then delayed for two weeks to rewrite the George Raft role to fit George Brent. Other items in Hollywood Reporter add that Lee Patrick replaced Geraldine Fitzgerald in the role of Delia Snedeker. The film was shot on location at Randsburg, CA, near Death Valley. Materials deposited in the Copyright Records add Abner Biberman to the cast, but he is not credited on screen, in the Call Bureau Cast Service lists, or in reviews.