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A March 1958 Hollywood Reporter news item announced the production of Guns, Girls and Gangsters starring Mamie Van Doren for Vogue Pictures and lists Orville Hampton as the screenwriter. Hampton's contribution, if any, to the final script has not been determined. Vogue was another company owned by executive producer Edward Small and it is likely that a decision was made to produce the film under his Imperial Pictures banner instead of Vogue.
According to a Daily Variety news item, band leader Ray Anthony, who was married to Van Doren at the time, was set for a role in the film. A July 1962 Daily Variety item notes that in 1960, Edward Small Productions and United Artists were sued for plagiarism by Art Estrada. The $150,000 suit claimed that a story, "Blueprint for Crime," written by Estrada and Steve Masino was offered to and rejected by Small, then sold to producer Al Gannaway. When Small's similarly themed Guns, Girls and Gangsters was released, Gannaway canceled his production. The case was settled out of court in July 1962 for $10,000.