- MGM wanted Cary Grant to play Byam, but Grant was under contract to Paramount, who refused to release him.
- 2nd unit assistant cameraman Glenn Strong died when a barge with 55 crewmen and staff members capsized when shooting exterior scenes.
- Charles Laughton, playing William Bligh, who performed one of the world's greatest feats of navigation after having been cast adrift at sea by the Bounty mutineers, was in reality terrified of the ocean and was violently seasick throughout most of the filming.
- Clark Gable had to shave off his trademark mustache for this film for historical accuracy. Mustaches were not allowed in the British Navy during the time the story takes place.
- Actor James Cagney was sailing his boat off of Catalina Island, California, and passed the area where the film's crew was shooting aboard the Bounty replica. Cagney called to director Frank Lloyd, an old friend, and said that he was on vacation and could use a couple of bucks, and asked if Lloyd had any work for him. Lloyd put him into a sailor's uniform and gave him a fake mustache and sideburns, and Cagney spent the rest of the day playing a sailor aboard the Bounty.
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