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Jack Finney's 5 Against the House was serialized in Good Housekeeping magazine July-September 1951. According to October 1954 Daily Variety news items, United Artists was originally set to release 5 Against the House with Frank Tashlin directing and his wife Mary Costa starring. Tashlin and Costa withdrew from the production when Columbia took over. Daily Variety news items record that Peter Godfrey was scheduled to replace Tashlin. According to the same items, Milly Vitale was under consideration for the role that eventually went to Kim Novak. Roddy McDowall and Robert Horton were also announced in starring roles but did not appear in the picture.
According to a September 1954 New York Times article, portions of the film were shot on location in Reno and Las Vegas, NV. A January 1954 Daily Variety news item indicates that filming was also set for Mill Valley, CA. The Daily Variety and Hollywood Reporter reviews incorrectly include actors John Zaremba, George Brand, Mark Hanna, Carroll McComas and Hugh Sanders in the cast. The actors actually appeared in the 1955 Columbia release Chicago Syndicate.