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Ralph Nelson's onscreen credit reads: "Written for the screen and directed by." A February 1971 Daily Variety news item indicated that London's Cineman Films, Ltd. (comprised of Stanley Mann, John Kohn and Peter Katz) had acquired rights to James Graham's novel The Wrath of God before its publication. In March 1971, Hollywood Reporter noted that Nelson had acquired the novel's rights in association with Cineman and had signed John Briley to write the screenplay. By July 1971, Daily Variety reported that Nelson had signed Clair Huffaker to write the script. Ultimately, Nelson himself received sole screen credit for the script, and the contributions by Briley or Huffaker to the released film have not been determined. Nelson also appeared in a bit role in the film.
In early January 1972, Hollywood Reporter stated that production had temporarily halted due to an injury to actor Ken Hutchison ("Emmet Keogh"), who had fractured his arm. A January 12, 1972 Variety article quoted Nelson as stating that production had stopped two days before Christmas and he understood that Hutchison had put his hand through a glass pane at his hotel. Although the article stated that the actor might need from three weeks to two months to recuperate, a January 28, 1972 Variety item noted that location filming was completed in Guanajuato, Mexico and would be resuming with interiors at Estudios Churubusco.
Although the novel was set in Mexico, the location of the story is not mentioned in the film. Some reviews refer to the location as Central or South America. The Aymara natives, of which "Chela" and "Nacho" are members, have been situated in the South American Andes for more than 2,000 years, in what is now Bolivia. According to the Los Angeles Times review, The Wrath of God was cited by the American Humane Association for alleged misuse of horses.
The Wrath of God marked the final film appearance of actress Rita Hayworth. Biographies indicate that although Hayworth went several years improperly diagnosed, she was likely already suffering from the memory-deteriorating Alzheimer's disease by the early 1970s, making it difficult for her to continue acting. Hayworth ultimately died from the effects of the disease in 1987.