- The studio had originally cast Ingrid Bergman in the Beatrix Emery role and Lana Turner in the Ivy Peterson role. Bergman felt the role of Ivy was more challening and persuaded the producers to switch roles with Turner.
- When author W. Somerset Maugham visited the set during the filming, he supposedly watched a bit of Spencer Tracy's performance and asked sardonically, "Which one is he now, Jekyll or Hyde?"
- The character of Ivy Peterson was taken not from Robert Louis Stevenson's original novella, but from the 1931 film version. Ivy never appears in the original story, nor, for that matter, does Jekyll's fiancee.
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