- Katharine Hepburn asked MGM to cast Clark Gable as Dexter and Spencer Tracy as Mike before she met either of them. Both Gable and Tracy were busy with other projects, so Cary Grant and 'James Stewart (I)' were cast instead.
- Playwright Philip Barry based the character of Tracy on Hepburn's public image at the time. She'd left her previous studio, RKO, on bad terms, which only worsened her (temporarily) unpopular image.
- This film was selected to the National Film Registry, Library of Congress, in 1995.
- The film was shot in eight weeks, and required no retakes. 'James Stewart' thought of hiccupping in the drunk scene himself, without telling Cary Grant. When he began hiccuping, Grant turned to Stewart saying, "Excuse me." The scene required only one take.
- Katherine Hepburn starred in the Broadway production of the play on which this film was based and owned the film rights to the material they were purchased for her by billionaire Howard Hughes then given to her as a gift.
- James Stewart had no plans to attend the Oscar ceremony the year he was nominated for this film. Just before the ceremony began, he received a call at home "advising" him to slip into a dinner jacket and attend the ceremony. He did and he received the award for Best Actor. This was in the days before an accounting firm kept the Oscar voting results secret.
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