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This film marked the directorial debut of Willis Goldbeck, who previously had written the "Dr. Kildare" and "Dr. Gillespie" films. According to news items in Hollywood Reporter, Edna Holland and Edith Evanson were cast in the film, but their appearances have not been confirmed. Although Selmer Jackson is listed in the CBCS as "Dr. Harrison," he was not in the released film; his character is referred to as being away in the Army. A news item in Hollywood Reporter on August 20, 1942 noted that Dr. H. A. Conway was to be the technical advisor on the film, taking over from the usual series advisor, Dr. Charles Mandell, who had recently entered the Army. The extent of Mandell's participation on this film has not been determined.
This was the first of four films in the Dr. Gillespie series in which Van Johnson portrayed "Dr. Red Adams," and Keye Luke portrayed "Dr. Lee Wong How." Johnson left the series in 1944 and Luke's final picture in the series was the last, Dark Delusion in 1947. Johnson and Luke assumed the role of Gillespie's "assistant," which had previously been occupied by Lew Ayres in films that were part of the Dr. Kildare series. Luke also portrayed Dr. How in the 1944 picture Andy Hardy's Blonde Trouble. For additional information on the "Dr. Kildare" and "Dr. Gillespie" series, consult the Series Index and see the entry above for Calling Dr. Gillespie, and the entry for Young Dr. Kildare in AFI Catalog of Feature Films, 1931-40; F3.5251.