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According to a February 1943 Hollywood Reporter news item, M-G-M paid $75,000 for the rights to Marcia Davenport's novel. A February 21, 1945 Hollywood Reporter news item notes that George Cukor took over direction of added scenes from Tay Garnett when Garnett became ill. A pre-production news item in Hollywood Reporter notes that John Hodiak was originally slated for the part played by Gregory Peck. The initial Hollywood Reporter production chart for the film lists Hume Cronyn in the cast, but he did not appear in the released film. According to modern sources, Cronyn was originally cast in the part of "Ted Scott," but was later replaced by Marshall Thompson because Cronyn appeared too short when standing beside Peck in the film. Early Hollywood Reporter production charts list Sara Allgood, Mary Philips and Edith Leach in the cast, and Hollywood Reporter news items include Alec Craig, Dorothy Russell and Robert and Richard Ganieri in the cast. Allgood, Philips and Craig were not in the released film, and the appearance of Leach and Robert and Richard Ganieri has not been confirmed. Actor Dean Stockwell made his motion picture debut in the film. Greer Garson was nominated for an Academy Award for Best Actress, and Herbert Stothart was nominated for Best Scoring of a Dramatic or Comedy Picture. The film received Photoplay's Best Picture award. On March 20, 1960, the CBS network aired a television version of The Valley of Decision, directed by Tom Donovan and starring Nancy Wickwier and Lloyd Bridges.