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The working title of this film was The Stars Can Wait. Although onscreen credits list Connie Gilchrist's character name as "Beulah," she is called "Delia Murphy" in the film. Except for a cameo appearance in M-G-M's 1943 picture The Youngest Profession (see below entry), The Heavenly Body marked William Powell's first picture since the 1942 film Crossroads . Crossroads was also the first time in which Powell co-starred with Hedy Lamarr, and according to modern sources, the success of that film prompted M-G-M to re-team them in The Heavenly Body.
M-G-M borrowed director Alexander Hall from Columbia for this production. In mid-July 1943, when Hall was forced to return to Columbia to begin work on Once Upon a Time , Vincente Minnelli took over as director for the remainder of the production. Although Robert Planck is credited onscreen as director of photography, William Daniels was listed as cameraman in all Hollywood Reporter production charts. In M-G-M publicity material, located in the file on the film at the AMPAS Library, Phillip Terry was listed in the role of "Whitley's" assistant, but he did not appear in the final film. Lloyd Ford, Bobby Waters and Rex Evans were listed by CBCS as cast members, but their parts were not included in the completed film. Although Arno Frey and Dudley Dickerson were listed in Hollywood Reporter news items as cast members, their appearance in the final film has not been confirmed.