Born in Buffalo, New York
Appeared in a Baltimore production of "She Stoops to Conquer"
Was member of the company of the McCarter Theatre in Princeton, New Jersey
Made Broadway debut in "Hide and Seek"
Had supporting role in the landmark CBS TV drama "Playing for Time"
Feature film debut, "Soup for One"
First garnered attention as a meter maid in Louis Malle's comedy "Crackers"
Co-starred Glenn Close in Tom Stoppard's Broadway comedy "The Real Thing"; directed by Mike Nichols
Replaced Judith Ivey on the Broadway stage in the acclaimed production of David Rabe's play, "Hurlyburly"
Replacing Stockard Channing as Bunny Flingus in the acclaimed Broadway revival of John Guare's comedy-drama, "The House of Blue Leaves" (reprised role in the TV version)
Co-starred on Broadway in the Neil Simon comedy "Rumors"; picked up second Tony Award
Portrayed Andrea Reynolds opposite Irons' Claus von Bulow and Close's Sunny von Bulow in "Reversal of Fortune"
Starred in the ill-fated musical "Nick and Nora"
Appeared in "Lips Together, Teeth Apart" at the Manhattan Theatre Club
Offered a strong comic turn as a camp counselor in "Addams Family Values"
Delivered another gemlike comic performance as Kevin Spacey's hoity-toity sister-in-law in "The Ref"
Cast as Cybill Shepherd's hard-drinking friend Maryanne Thorpe in the CBS sitcom "Cybill"
Appeared as Robin Williams' ex-wife in the Mike Nichols-directed "The Birdcage"
Starred in the Encores! presentation of "Promises, Promises" opposite Martin Short at Manhattan's City Center
Played the wife of Warren Beatty's suicidal US Senator in the political comedy "Bulworth"
Had featured role as a rauchy biker chick in "The Odd Couple II"
Garnered an Emmy nomination for her memorable guest appearance on NBC's "Frasier" as radio host Dr. Nora
Returned to the stage as Mrs. Lovett in L.A.'s Reprise! concert production of "Sweeney Todd" co-starring Grammer
Played fading diva opposite Steve Martin and Eddie Murphy in the comedy "Bowfinger"
Executive produced and starred in the short-lived CBS sitcom "Welcome to New York"
Had featured role as the title character's childhood sweetheart in "How the Grinch Stole Christmas"
Cast as Mrs. Lovett in the Kennedy Center production of "Sweeney Todd"
Played reporter Mary Sunshine in the film version of "Chicago"
Appeared in the Hollywood/Bollywood satire "The Guru"
Co-starred with John Larroquette in the NBC sitcom "Happy Family"
Appeared in the comedy "Welcome to Mooseport"
Played the title role in the Broadway revival of "Mame" at the Kennedy Center
Starred in the Broadway revival of "Boeing-Boeing"
Cast in the film adaptation of the ABBA stage musical "Mamma Mia!"
Played Dr. Beverly Hofstadter, an unemotional expert in psychiatry and neural science, and Leonard¿s (Johnny Galecki) mom in "The Big Bang Theory"
Cast opposite Julianna Margulies in the CBS drama, "The Good Wife"
Nominated for the 2011 Primetime Emmy Award for Outstanding Supporting Actress In A Drama Series