Cast in the film adaptation of the ABBA stage musical "Mamma Mia!"
Cast opposite Julianna Margulies in the CBS drama, "The Good Wife"
Co-starred with John Larroquette in the NBC sitcom "Happy Family"
Feature film debut, "Soup for One"
First garnered attention as a meter maid in Louis Malle's comedy "Crackers"
Played reporter Mary Sunshine in the film version of "Chicago"
Played the title role in the Broadway revival of "Mame" at the Kennedy Center
Appeared in a Baltimore production of "She Stoops to Conquer"
Born in Buffalo, New York
Co-starred Glenn Close in Tom Stoppard's Broadway comedy "The Real Thing"; directed by Mike Nichols
Delivered another gemlike comic performance as Kevin Spacey's hoity-toity sister-in-law in "The Ref"
Executive produced and starred in the short-lived CBS sitcom "Welcome to New York"
Garnered an Emmy nomination for her memorable guest appearance on NBC's "Frasier" as radio host Dr. Nora
Had featured role as a rauchy biker chick in "The Odd Couple II"
Had supporting role in the landmark CBS TV drama "Playing for Time"
Replaced Judith Ivey on the Broadway stage in the acclaimed production of David Rabe's play, "Hurlyburly"
Replacing Stockard Channing as Bunny Flingus in the acclaimed Broadway revival of John Guare's comedy-drama, "The House of Blue Leaves" (reprised role in the TV version)
Starred in the Encores! presentation of "Promises, Promises" opposite Martin Short at Manhattan's City Center
Starred in the ill-fated musical "Nick and Nora"
Appeared as Robin Williams' ex-wife in the Mike Nichols-directed "The Birdcage"
Appeared in the comedy "Welcome to Mooseport"
Appeared in the Hollywood/Bollywood satire "The Guru"
Co-starred on Broadway in the Neil Simon comedy "Rumors"; picked up second Tony Award
Played Dr. Beverly Hofstadter, an unemotional expert in psychiatry and neural science, and Leonard's (Johnny Galecki) mom in "The Big Bang Theory"
Had featured role as the title character's childhood sweetheart in "How the Grinch Stole Christmas"
Offered a strong comic turn as a camp counselor in "Addams Family Values"
Played the wife of Warren Beatty's suicidal US Senator in the political comedy "Bulworth"
Portrayed Andrea Reynolds opposite Irons' Claus von Bulow and Close's Sunny von Bulow in "Reversal of Fortune"
Returned to the stage as Mrs. Lovett in L.A.'s Reprise! concert production of "Sweeney Todd" co-starring Grammer
Was member of the company of the McCarter Theatre in Princeton, New Jersey
Appeared in "Lips Together, Teeth Apart" at the Manhattan Theatre Club
Cast as Cybill Shepherd's hard-drinking friend Maryanne Thorpe in the CBS sitcom "Cybill"
Cast as Mrs. Lovett in the Kennedy Center production of "Sweeney Todd"
Made Broadway debut in "Hide and Seek"
Played fading diva opposite Steve Martin and Eddie Murphy in the comedy "Bowfinger"
Starred in the Broadway revival of "Boeing-Boeing"
Nominated for the 2011 Primetime Emmy Award for Outstanding Supporting Actress In A Drama Series