Raised in Wheaton, IL, and in Seattle, WA
Made TV debut in the ABC Afterschool Special, "Taking a Stand"
Played Marty, Alex Keaton's love interest, in the NBC series "Family Ties"
Film debut, "Vital Signs"
Broadway debut, "I Hate Hamlet"
Won acclaim (and a Tony Award) for her co-starring role in the Broadway production of "An Inspector Calls"
Played a doctor in "Father of the Bride Part II," alongside Steve Martin and Diane Keaton
Was an ensemble cast member of "Kansas City," directed by Robert Altman
Debuted as a series regular on the ABC drama, "Relativity"
Starred in the controversial feature "Happiness," directed by Todd Solondz
Played the recurring role of Dr. Mel Karnofsky, who became Niles's second wife on the hit sitcom "Frasier" (NBC)
Appeared in the Sundance screened "Songcatcher" as the schoolteacher sister of the lead character
Cast as a neurotic actress in "The Anniversary Party"
Played a close friend of Jim Carrey's in the Michel Gondry directed, "Eternal Sunshine of the Spotless Mind"; co-scripted by Gondry and Charlie Kaufman
Had a small role in Todd Field's "Little Children"
Co-starred with Jodie Foster in the crime drama, "The Brave One"
Cast as Tanya Skagle, a wannabe pimp, in the HBO comedy series "Hung"; earned a Golden Globe nomination in 2009 for Best Supporting Actress