Moved with parents to Beverly Hills, CA at age three
Parents Henry and Phoebe Ephron reportedly used her college letters to home as the inspiration for the 1961 Broadway hit "Take Her, She's Mine"
"Take Her, She's Mine" adapted into a feature film starring James Stewart and Sandra Dee
Hired as reporter for the <i>New York Post</i>; also worked as freelance writer, contributing to such publications as <i>The New York Times Magazine</i> and <i>Good Housekeeping</i>
Published first collection of essays <i>Wallflower at the Orgy</i>
Named a columnist and contributing editor at <i>Esquire</i> magazine
Wrote for the short-lived ABC sitcom "Adam's Rib"
Named contributing editor at <i>New York</i> magazine
Promoted to senior editor at <i>Esquire</i>
Published second collection of essays <i>Crazy Salad: Some Things About Women</i>
Wrote the CBS movie "Perfect Gentlemen," starring Lauren Bacall
Co-wrote first screenplay "Silkwood," directed by Mike Nichols and starring Meryl Streep; earned first Academy Award nomination for Best Original Screenplay
Published first novel <i>Heartburn</i>, which was loosely based on the break-up of her second marriage to Carl Bernstein
Penned screenplay adaptation of "Heartburn," directed by Nichols, and starring Streep and Jack Nicholson
Made a cameo as a wedding guest in Woody Allen's "Crimes and Misdemeanors"
Garnered second Academy Award nomination for writing "When Harry Met Sally..."; film directed by Rob Reiner, and co-starring Billy Crystal and Meg Ryan
Made feature directorial debut with "This Is My Life"; also co-wrote with sister Delia Ephron
Played a dinner party guest in Woody Allen's "Husbands and Wives"
Re-teamed with Meg Ryan to direct her and Tom Hanks in the hit romantic comedy "Sleepless in Seattle"; also co-wrote, earning third Best Original Screenplay Academy Award nomination
Directed the critically panned "Mixed Nuts"; re-teamed with sister Delia to write the screenplay
Produced and directed the comedy "Michael," starring John Travolta; also co-wrote with sister Delia
Re-teamed with Tom Hanks and Meg Ryan for romantic comedy "You've Got Mail"; co-wrote screenplay with sister Delia
Produced and co-wrote screenplay (with sister Delia) for "Hanging Up"; film directed by Diane Keaton, who also co-starred with Meg Ryan and Lisa Kudrow
Scripted first play "Imaginary Friends," about the relationship between writers Lillian Hellman and Mary McCarthy; first premiered at the Old Globe Theatre in San Diego, CA before moving to Broadway's Ethel Barrymore Theatre
Directed the big screen adaptation of the 1960s classic TV series "Bewitched," starring Nicole Kidman and Will Ferrell; also produced and co-wrote with sister Delia
Wrote the book <i>I Feel Bad About My Neck: And Other Thoughts on Being a Woman</i>
Re-teamed with star Meryl Streep to direct "Julie & Julia"; also produced and penned the screenplay adaptation of Julie Powell's book about cooking 524 recipes from Child's <i>Mastering the Art of French Cooking</i>
Published the collection of essays titled <i>I Remember Nothing: And other Reflections</i>