Spent one season as a member of the Theatre Company of Boston
Acted with Trinity Square Repertory Company in Providence, RI
Was cast in her first Broadway show, the musical "Mata Hari"; show closed during out-of-town tryout
Had a supporting role in the NBC production of the Broadway musical "George M!"
Played featured role in the ABC TV-movie "Dr. Cook's Garden"
Portrayed Martha Jefferson in the movie version of "1776"
Played a jilted wife opposite Peter Falk and John Cassavetes on an episode of "Columbo" (NBC)
Cast as Amanda on the short-lived ABC sitcom "Adam's Rib"
Played a woman who comes between two friends in "Lovin' Molly"
Portrayed Zelda to Richard Chamberlain's F. Scott Fitzgerald in "F. Scott Fitzgerald and The Last of the Belles'" (ABC)
Portrayed Elizabeth Custer in "The Court-Martial of General George Armstrong Custer" (ABC)
Earned critical praise as Eleanor Gehrig in "A Love Affair: The Eleanor and Lou Gehrig Story" (NBC)
Returned to Broadway appearing alongside Raul Julia and Roy Scheider in Harold Pinter's "Betrayal"; earned a Tony nomination
Starred in the Lincoln Center revival of "The Philadelphia Story"
Portrayed the wife of German architect Albert Speer in the ABC miniseries "Inside the Third Reich"
Made guest appearance on an episode of "St. Elsewhere" (NBC)
Played the wife of a philandering attorney (Anthony Hopkins) who was plotting to kill her in "Guilty Conscience" (CBS)
Co-starred with Richard Chamberlain and Judith Ivey in a revival of Noel Coward's "Blithe Spirit"
Earned a Tony nomination as Blanche Du Bois in a stage revival of "A Streetcar Named Desire"
Played the co-owner of a NYC restaurant on the short-lived NBC drama, "Tattinger's"; series was retooled as an NBC sitcom called "Nick & Hillary," which lasted only a handful of episodes
Appeared in Woody Allen's "Another Woman"
Cast as the mother of a child molested by a priest in the HBO drama "Judgment"
Co-starred with Paul Newman and Joanne Woodward in "Mr. & Mrs. Bridge"
Made second film with Woody Allen, "Alice"
Portrayed Nick Nolte's wife in "The Prince of Tides"
Re-teamed with daughter Gwyneth Paltrow in the NBC miniseries "Cruel Doubt"
Portrayed Arkadina in Williamstown production of "The Seagull" with daughter Gwyneth Paltrow as Nina
Appeared Off-Broadway in A. R. Gurney's "Sylvia"
Portrayed the matriarch of a troubled family in "The Myth of Fingerprints"
Voiced Martha Jefferson in Ken Burns' PBS documentary "Thomas Jefferson"
Hosted "Sophisticated Ladies: Charleston and Savannah With Blythe Danner" (PBS)
Played Kate Capshaw's mother in "The Love Letter"
Co-starred with Edward Herrmann in a staged reading of A. R. Gurney's "Ancestral Voices"
Cast as Robert De Niro's understanding wife in the comedy "Meet the Parents"
Played the mother of Cameron Diaz and Jordana Brewster in "The Invisible Circus"
Cast as Phyllis in the all-star Broadway revival of "Follies"; received a Tony nomination
Cast as Dr. Harriet Lanning on the short-lived CBS medical drama "Presidio Med"
Portrayed Sylvia Plath's mother opposite her real life daughter Gwyneth Paltrow in "Sylvia"
Reprised her role as Dina Byrnes for the comedy sequel, "Meet the Fockers"
Starred in the TV-movie "Back When We Were Grownups" (CBS); received Golden Globe and Emmy nominations for Best Actress
Co-starred in "The Last Kiss"; directed by Tony Goldwyn and scripted by Paul Haggis
Once again reprised the role of Dina Byrnes for the comedy sequel "Little Fockers"
Co-starred with Zac Efron in "The Lucky One," based on the novel by Nicholas Sparks
Cast in romantic comedy "Hello I Must Be Going," starring Melanie Lynskey
Starred in the TV movie "Gilded Lilys"
Co-starred in the dark comedy "Murder of a Cat"
Appeared in romantic comedy "Tumbledown"