Portrayed a crooked police officer in Martin Scorsese's acclaimed crime drama "The Departed."
Began a recurring role as Liz Lemon's airline pilot love interest on the sitcom "30 Rock."
Won the lead role of Jason Bourne in the massively popular espionage thriller in "The Bourne Identity," based on the Robert Ludlum novel.
Played his first prominent screen role in the movie "School Ties," also featuring his friend Ben Affleck.
Reteamed with Affleck to play a pair of renegade angels in Kevin Smith's "Dogma."
Appeared on and acted as executive producer with Ben Affleck and others in the HBO series "Project Greenlight" which followed the making of the film "Stolen Summer."
Made his feature film debut with a one-line role in "Mystic Pizza."
Starred in "John Grisham's 'The Rainmaker,'" directed by Francis Ford Coppola.
Landed a deal to co-star with Ben Affleck in a script the two co-wrote, "Good Will Hunting," which received an Oscar for Best Original Screenplay.
Appeared in the ensemble film "Ocean's Eleven."
Co-starred with Gwyneth Paltrow and Jude Law in "The Talented Mr Ripley," scripted and directed by Anthony Minghella.
Portrayed Francois Pienaar, the South African Rugby team captain, opposite Morgan Freeman as former President Mandela in Clint Eastwood's "Invictus."
Joined an ensemble cast for Steven Soderbergh's "Contagion."
Played the titular role in Steven Spielberg's WWII drama "Saving Private Ryan."
Portrayed Mark Whitacre, the ADM executive turned whistle-blower in Steven Soderbergh's "The Informant."
With Casey Affleck, co-wrote and co-starred in the Sundance-screened "Gerry."
Was cast in Terry Gilliam's "The Brothers Grimm" opposite Heath Ledger.
Guest starred on the NBC sitcom "Will & Grace," playing a heterosexual who poses as a gay man to land a spot in a chorale group.
Re-teamed with his franchise castmates for "Ocean's 13."
Received a star on the Hollywood Walk of Fame.
Reprised role of Jason Bourne for "The Bourne Ultimatum."
Starred in the film version of the Cormac McCarthy novel <i>All the Pretty Horses</i>, scripted and directed by Billy Bob Thornton.
Made his TV acting debut in the TV-movie "Rising Son."
Played an oil executive in the geopolitical thriller "Syriana," based on the real-life memoirs of CIA agent Robert Baer; produced by George Clooney.
Executive produced "Feast," a horror film, which is a result of the third season of "Project Greenlight."
Played the leading role of a reformed gambler in "Rounders."
Portrayed a 1930s golfer in "The Legend of Bagger Vance," directed by Robert Redford.
Re-teamed with director Paul Greengrass for the war thriller "Green Zone."
Co-starred with Greg Kinnear in the comedy "Stuck on You," directed by Peter and Bobby Farrelly.
Landed a supporting role in "Courage Under Fire."
Sponsored Project Greenlight, an Internet screenwriting competition created in partnership with HBO and Miramax.
Made a cameo appearance in "Chasing Amy," starring Affleck and directed by Kevin Smith.
Portrayed CIA agent Edward Wilson in Robert De Niro's long-anticipated "The Good Shepherd," which recounts the history of the CIA from World War II through its involvement in the Bay of Pigs.
Reprised role of Jason Bourne in "The Bourne Supremacy" based on the Robert Ludlum novel.
Returned with the original cast of "Ocean's Eleven" for "Ocean's Twelve," directed by Steven Soderbergh.
Played an American factory worker who communicates with the dead in "Hereafter," a film written by Peter Morgan and directed by Clint Eastwood.
Played Texas Ranger La Boeuf in the remake of the Western "True Grit," written and directed by the Coen brothers.
Starred opposite Emily Blunt in the romantic thriller "The Adjustment Bureau."
Co-starred with Anna Paquin and Mark Ruffalo in the film "Margaret"; which would spend five years in post-production.
Played a father who moves his family to the countryside to renovate a struggling zoo in "We Bought a Zoo," directed by Cameron Crowe and co-starring Scarlett Johansson.
Voiced the character of Bill the Krill in the animated sequel "Happy Feet Two."
Starred in and co-wrote the screenplay for "Promised Land" with John Krasinski, a film based on a story by Dave Eggers and directed by Gus van Sant.
Appeared in the Christopher Nolan science fiction film "Interstellar."
Featured in the HBO TV movie "Behind the Candelabra."
Played a stranded astronaut in "The Martian."