Appeared on Broadway opposite Sam Waterston in "Benefactors"
Cast as First Lady to Jack Nicholson's President in "Mars Attacks!"
Cast opposite Jeremy Irons as Sunny von Bulow in "Reversal of Fortune"
Cast opposite Timothy Olyphant in "The Safety of Objects"; screened at Toronto Film Festival
Starred as a mother whose son has returned home to die in the HBO movie "In the Gloaming"; directed by Christopher Reeve
Joined Phoenix Theatre Company in NYC and made Broadway debut in their production of "Love for Love"
Made cameo appearance as a male pirate in Steven Spielberg's "Hook"
Played Gertrude to Mel Gibson's "Hamlet"; directed by Franco Zeffirelli
Reprised role of Sarah in "Sarah, Plain and Tall: Winter's End," the third installment for CBS and "Hallmark Hall of Fame"
Reprised the role of Sarah in the sequel "Skylark" (CBS)
Returned to the stage as Norma Desmond in the Andrew Lloyd Webber musical version of "Sunset Boulevard"
Appeared in Rodrigo Garcia's "Nine Lives," an ensemble feature about nine short, loosely intertwining tales
Guest starred as a potential Supreme Court justice on the NBC drama "The West Wing"
Joined the cast of FX's "The Shield" in season four, playing the new captain of the Farmington precinct
Played lead role in the off-Broadway production of "The Singular Life of Albert Nobbs"
Produced and starred in the TNT original movie "Rachel Carson's Silent Spring"
Co-starred with Patrick Stewart in Showtime's remake of "A Lion in Winter," story by James Goldman
Co-starred with William Hurt in the staging of the oratorio "Joan of Arc at the Stake" in NYC
Played Colonel Margarethe Cammermeyer, who disclosed her lesbianism in NBC's "Serving in Silence: The Margarethe Cammermeyer Story"; also executive produced
Portrayed Nelly Forbush in the small screen remake of "South Pacific" (ABC)
Returned to Broadway as co-star of Tom Stoppard's "The Real Thing"; directed by Mike Nichols and co-starred Jeremy Irons; won first of three Tony Awards
Associate produced first project (a documentary; also narrated), "Do You Mean There Are Still Real Cowboys?" for PBS "American Experience" series
Made Broadway musical debut as Mary Tudor in the Richard Rodgers-Sheldon Harnick show "Rex"
Cast opposite Nicole Kidman and Bette Midler in the remake of ''The Stepford Wives,'' Bryan Forbes' 1975 cult classic about upper-crust women being replaced by robots with sunny dispositions
Co-starred with Ted Danson in ABC TV movie "Something About Amelia"
Played the US Vice President coping with a hostage crisis involving the First Family in "Air Force One"
Portrayed Cruella de Vil in the live-action Disney film, "101 Dalmatians"
Reprised role of Cruella de Vil in "102 Dalmatians"
Starred as an eccentric Southerner in Robert Altman's "Cookie's Fortune"
Made TV-movie debut in "Too Far to Go" (NBC)
Lent her voice to the animated feature, "Hoodwinked!"
Reprised role of Granny Puckett in "Hoodwinked Too! Hood vs. Evil"
Co-starred in drama "Low Down," about the relationship between a troubled jazz musician and his daughter
Had supporting role in Tim Blake Nelson's thriller "Anesthesia"
Played a doctor in horror drama "The Girl with All the Gifits"
Co-starred with Owen Wilson, Ed Helm and Christopher Walken in ensemble comedy "Father Figures"
Appeared in crime drama "Easter"
Starred in first Broadway role in six years in "Death and the Maiden" with Richard Dreyfuss and Gene Hackman
Produced and starred in TV movie "Sarah, Plain and Tall"
Co-starred in Baby Boomer drama "The Big Chill"
Made screen debut in "The World According to Garp"; received first of three consecutive Oscar nominations as Best Supporting Actress
Played Alex in erotic thriller "Fatal Attraction"
Cast as ruthless litigator Patty Hewes in the FX legal drama, "Damages"
Landed first leading film role in drama "Jagged Edge"
Portrayed Charity Barnum in the stage musical biography "Barnum"; earned first Tony Award nomination; also appeared in the show's national tour
Co-starred as Roy Hobbs' girlfriend in "The Natural"
Played the manipulative Marquise de Merteuil in "Dangerous Liaisons"
Co-wrote and starred in the period drama "Albert Nobbs," based on the short story by George Moore; also produced
Co-starred in adventure comedy "Guardians of the Galaxy"
Had recurring role on "The SImpsons" as Homer's estranged mother Mona