Co-starred with Keri Russell in the indie, "Waitress"; helmed by Adrienne Shelly, who was murdered before the films release
Appeared in an episode of "The Outer Limits" (Showtime) as a futuristic freedom fighter
Starred as the local sheriff in the horror film "Slither"
Joined the sitcom "Two Guys, a Girl, and a Pizza Place" in a supporting role; became a regular cast member in the second season
Was featured as the jealous ex-boyfriend of Alicia Silverstone in "Blast From the Past"
Cast in the lead role of Alex Tully in the short-lived series, "Drive" (Fox)
Reprised his role as Joey on two episodes of ABC's "One Life to Live"
Appeared in Whedon's adaptation of "Much Ado About Nothing"
Voiced Johnny Worthington in "Monsters University"
Appeared in the sequel "Percy Jackson: Sea of Monsters"
Had a vocal cameo in Marvel's "Guardians of the Galaxy"
Played Joey Buchanan on the ABC soap opera, "One Life to Live"
Starred as Captain Malcolm Reynolds in the Joss Whedon series "Firefly"
Reprised his role as Captain Reynolds in "Serenity," Whedon's feature-length sequel to "Firefly"
Made first TV appearance in the ABC movie "Ordeal in the Arctic"
Made his feature film debut in Steven Spielberg's "Saving Private Ryan," playing a soldier with the same name as the sought after James Ryan
Had a recurring role as Caleb in the final season of Joss Whedon's series "Buffy the Vampire Slayer"
Joined the cast of ABC's "Desperate Housewives" as Dr. Adam Mayfair
Appeared in Joss Whedon's Internet-distributed short "Dr. Horrible's Sing-Along Blog" as Captain Hammer
Played the title character of Richard Castle, a mystery novelist who helps the NYPD solve crimes in ABC's "Castle"
Had a recurring role on "Gravity Falls"
Appeared as Wernher Von Braun on "Drunk History"
Played Jack Moore on "Con Man"
Cast as weatherman Rainer Shine on "Modern Family"
Appeared in the pilot for Netflix's gross-out comedy/drama "Santa Clarita Diet"
Voiced Sterling in Disney/Pixar sequel "Cars 3"