Worked as freelance interior decorator before getting first film job
Made her film debut in "Star Trek II: The Wrath of Khan"
Had a recurring role on the short-lived spy series "Masquerade" (ABC)
Appeared in the science fiction action film "Runaway," starring Tom Selleck
Portrayed journalist Gloria Steinem in the TV movie "A Bunny's Tale" (ABC)
Co-starred in ABC historical miniseries "North and South"
Cast opposite Mark Harmon in the comedy "Summer School"
Joined the cast of "Cheers" (NBC) as Sam Malone's (Ted Danson) boss, Rebecca Howe; earned several Emmy nominations for Outstanding Lead Actress in a Comedy Series (1988, 1990, 1992 and 1993); also earned Golden Globe nominations for Best Actress in a Comedy series (1990, 1992 and 1993)
Appeared opposite Patrick Dempsey in "Loverboy"
Co-starred with John Travolta in the comedy "Look Who's Talking," written and directed by Amy Heckerling
Re-teamed with John Travolta and Amy Heckerling for "Look Who's Talking Too"
Returned for a third time for "Look Who's Talking Now"
Starred in the Lifetime movie "David's Mother," about a single mother raising her autistic son; received a Golden Globe nomination for Best Actress in a TV Movie
Received star on Hollywood Walk of Fame in November
Made producing debut with the TV-movie "Suddenly" (ABC); also starred
Cast in Woody Allen's "Deconstructing Harry"
Starred on the NBC sitcom "Veronica's Closet"; also served as producer; nominated for a Golden Globe and an Emmy for Outstanding Lead Actress in a Comedy Series (1998)
Played the mother of a beauty pageant contestant (Denise Richards) in the dark comedy "Drop Dead Gorgeous"
Published memoir <i>How to Lose Your Ass and Regain Your Life</i>
Battled with public perceptions in "Fat Actress," a semi-autobiographical comedy for Showtime; also served as co-creator and executive producer
Featured in "Kirstie Alley's Big Life," a semi-scripted reality series on A&E
Joined the 12th season of ABC's "Dancing with the Stars"; placed second in the competition
Returned for 15th season of "Dancing with the Stars," featuring all-stars lineup
Published second memoir <i>The Art of Men (I Prefer Mine al Dente)</i>