Cast opposite Mark Harmon in the comedy "Summer School"
Made producing debut with the TV-movie "Suddenly" (ABC); also starred
Re-teamed with John Travolta and Amy Heckerling for "Look Who's Talking Too"
Appeared opposite Patrick Dempsey in "Loverboy"
Made her film debut in "Star Trek II: The Wrath of Khan"
Received star on Hollywood Walk of Fame in November
Returned for a third time for "Look Who's Talking Now"
Appeared in the science fiction action film "Runaway," starring Tom Selleck
Co-starred with John Travolta in the comedy "Look Who's Talking," written and directed by Amy Heckerling
Had a recurring role on the short-lived spy series "Masquerade" (ABC)
Joined the cast of "Cheers" (NBC) as Sam Malone's (Ted Danson) boss, Rebecca Howe; earned several Emmy nominations for Outstanding Lead Actress in a Comedy Series (1988, 1990, 1992 and 1993); also earned Golden Globe nominations for Best Actress in a Comedy series (1990, 1992 and 1993)
Played the mother of a beauty pageant contestant (Denise Richards) in the dark comedy "Drop Dead Gorgeous"
Worked as freelance interior decorator before getting first film job
Battled with public perceptions in "Fat Actress," a semi-autobiographical comedy for Showtime; also served as co-creator and executive producer
Cast in Woody Allen's "Deconstructing Harry"
Starred in the Lifetime movie "David's Mother," about a single mother raising her autistic son; received a Golden Globe nomination for Best Actress in a TV Movie
Starred on the NBC sitcom "Veronica's Closet"; also served as producer; nominated for a Golden Globe and an Emmy for Outstanding Lead Actress in a Comedy Series (1998)
Portrayed journalist Gloria Steinem in the TV movie "A Bunny's Tale" (ABC)
Featured in "Kirstie Alley's Big Life," a semi-scripted reality series on A&E
Published memoir <i>How to Lose Your Ass and Regain Your Life</i>
Joined the 12th season of ABC's "Dancing with the Stars"; placed second in the competition
Co-starred in ABC historical miniseries "North and South"
Returned for 15th season of "Dancing with the Stars," featuring all-stars lineup
Published second memoir <i>The Art of Men (I Prefer Mine al Dente)</i>