Cast in the network satire "The TV Set," directed by Jake Kasdan and starring David Duchovny
Cast opposite Tina Fey and Amy Poehler in the comedy "Baby Mama"
Co-starred in the Broadway production of "Hurlyburly," directed by Mike Nichols; received a Tony nomination
Formed Goat Cay Productions
Re-teamed with Kline in Ang Lee's mood piece "The Ice Storm"
Teamed with Julianne Moore for the screen version of the novel "A Map of the World"
TV debut as a regular on the NBC soap "Somerset"; appeared alongside Ted Danson and JoBeth Williams
With Jennifer Love Hewitt, played a mother-daughter con team in "Heartbreakers"
Co-starred in the romantic comedy "You Again" with Jamie Lee Curtis and Betty White
Appeared in the John Singleton directed action thriller "Abduction"
Cast in the crime drama "Rampart" opposite Woody Harrelson
Made a cameo as The Director in the horror thriller "The Cabin in the Woods"
Cast alongside Robert De Niro and Cillian Murphy in thriller "Red Lights"
Co-starred with Bruce Willis and Henry Cavill in action thriller "The Cold Light of Day"
Appeared in the historical drama "Exodus: Gods and Kings"
Co-starred in the action-drama "Chappie"
Nabbed a supporting role in the children's fantasy film "A Monster Calls"
Appeared in the 2016 reboot of "Ghostbusters"
Had bit part as Woody Allen's movie date in "Annie Hall"
Portrayed gorilla conservationist Dian Fossey in "Gorillas in the Mist"; received one of two Oscar nominations that year for Best Actress; became the first actor nominated in two categories not to win either
Portrayed a ruthless business woman in "Working Girl"; received one of two Oscar nominations that year for Best Supporting Actress; became the first actor nominated in two categories not to win either
Had female lead of Dana Barrett in the blockbuster comedy "Ghostbusters"
Played a Manhattan socialite in the Truman Capote biopic "Infamous"
Reprised her role as Ripley in James Cameron's "Aliens"; earned an Oscar nomination for Best Actress
Starred in the USA Network miniseries "Political Animals" as a former First Lady-turned-Secretary of State
Played herself in the Pixar animated film "Finding Dory"
Again reprised Ripley for David Fincher's "Alien 3"; debuted as a producer
Breakthrough film role as franchise protagonist Ellen Ripley in Ridley Scott's sci fi epic "Alien"
Film acting debut in "Madman" (Israel)
Off-Broadway debut in Christopher Durang's "The Nature and Purpose of the Universe"
Played Eve, a woman whose 16 year old stepson falls in love with her in "Tadpole"
Re-teamed with James Cameron for the 3-D science fiction epic film "Avatar"
Received star on the Hollywood Walk of Fame (December 16)
Starred in the play-turned-motion picture drama "The Guys"
Starred with Jeff Daniels in the family drama "Imaginary Heroes"
TV-movie debut as the wicked stepmother in "Snow White: A Tale of Terror" (original intended for theatrical release but aired on Showtime); earned an Emmy nomination
Appeared as an agoraphobic psychologist in "Copycat" opposite Holly Hunter
Began using the name Sigourney (after a character mentioned in "The Great Gatsby")
Co-starred opposite Mel Gibson in Peter Weir's "The Year of Living Dangerously"
First onscreen teaming with Kevin Kline in "Dave"
Portrayed an autistic woman opposite Alan Rickman in "Snow Cake"
Returned to Broadway as the star of Christopher Durang's "Sex and Longing"
Returned to the NYC stage in "The Guys"; performed off-off-Broadway at the Flea, a company run by her husband
Returned to the U.S. and enrolled at Yale
Starred in M. Night Shyamalan's "The Village" with William Hurt and Joaquin Phoenix
After attending Stanford, moved to Israel and lived on a kibbutz
Appeared with Meryl Streep in the chorus of the Stephen Sondheim adaptation of "The Frogs" performed at Yale
Had featured role in "Company Man"
Made early stage appearances in Southbury, CT
Played a clone of Ripley in "Alien Resurrection"
Played a devout Christian who came to terms with her son's homosexuality after his suicide in the Lifetime movie "Prayers for Bobby"; earned Emmy, Golden Globe and SAG nominations for Best Actress in a TV Movie
Reprised role of Dana Barrett in "Ghostbusters II"
Was the warden in the teen feature "Holes"
With Durang, co-wrote and co-starred in "Das Lusitania Songspiel"; produced off-off-Broadway
Broadway debut (as understudy) in "The Constant Wife"
Cast as a news producer in the ensemble thriller "Vantage Point"