Film acting debut in "Madman" (Israel)
Off-Broadway debut in Christopher Durang's "The Nature and Purpose of the Universe"
Played Eve, a woman whose 16 year old stepson falls in love with her in "Tadpole"
Starred in the play-turned-motion picture drama "The Guys"
Starred with Jeff Daniels in the family drama "Imaginary Heroes"
Appeared as an agoraphobic psychologist in "Copycat" opposite Holly Hunter
Co-starred opposite Mel Gibson in Peter Weir's "The Year of Living Dangerously"
Portrayed an autistic woman opposite Alan Rickman in "Snow Cake"
Returned to Broadway as the star of Christopher Durang's "Sex and Longing"
Returned to the NYC stage in "The Guys"; performed off-off-Broadway at the Flea, a company run by her husband
Starred in M. Night Shyamalan's "The Village" with William Hurt and Joaquin Phoenix
Appeared with Meryl Streep in the chorus of the Stephen Sondheim adaptation of "The Frogs" performed at Yale
Had featured role in "Company Man"
Played a clone of Ripley in "Alien Resurrection"
With Durang, co-wrote and co-starred in "Das Lusitania Songspiel"; produced off-off-Broadway
Cast as a news producer in the ensemble thriller "Vantage Point"
Cast in the network satire "The TV Set," directed by Jake Kasdan and starring David Duchovny
Cast opposite Tina Fey and Amy Poehler in the comedy "Baby Mama"
Co-starred in the Broadway production of "Hurlyburly," directed by Mike Nichols; received a Tony nomination
Teamed with Julianne Moore for the screen version of the novel "A Map of the World"
TV debut as a regular on the NBC soap "Somerset"; appeared alongside Ted Danson and JoBeth Williams
With Jennifer Love Hewitt, played a mother-daughter con team in "Heartbreakers"
Co-starred in the romantic comedy "You Again" with Jamie Lee Curtis and Betty White
Appeared in the John Singleton directed action thriller "Abduction"
Cast in the crime drama "Rampart" opposite Woody Harrelson
Cast alongside Robert De Niro and Cillian Murphy in thriller "Red Lights"
Co-starred with Bruce Willis and Henry Cavill in action thriller "The Cold Light of Day"
Appeared in the historical drama "Exodus: Gods and Kings"
Nabbed a supporting role in the children's fantasy film "A Monster Calls"
Re-teamed with James Cameron for the 3-D science fiction epic film "Avatar"
Received star on the Hollywood Walk of Fame
Made TV-movie debut as the wicked stepmother in "Snow White: A Tale of Terror"; earned an Emmy nomination
Began using the name Sigourney (after a character mentioned in "The Great Gatsby")
First onscreen teaming with Kevin Kline in "Dave"
Again reprised Ripley for David Fincher's "Alien 3"; debuted as a producer
Breakthrough film role as franchise protagonist Ellen Ripley in Ridley Scott's sci fi epic "Alien"
Had bit part as Woody Allen's movie date in "Annie Hall"
Portrayed gorilla conservationist Dian Fossey in "Gorillas in the Mist"; received one of two Oscar nominations that year for Best Actress; became the first actor nominated in two categories not to win either
Portrayed a ruthless business woman in "Working Girl"; received one of two Oscar nominations that year for Best Supporting Actress; became the first actor nominated in two categories not to win either
Played a devout Christian who came to terms with her son's homosexuality after his suicide in the Lifetime movie "Prayers for Bobby"; earned Emmy, Golden Globe and SAG nominations for Best Actress in a TV Movie
Reprised role of Dana Barrett in "Ghostbusters II"
Was the warden in the Disney teen adventure "Holes"
Made Broadway debut as an understudy in "The Constant Wife"
Had female lead of Dana Barrett in the blockbuster comedy "Ghostbusters"
Played a Manhattan socialite in the Truman Capote biopic "Infamous"
Re-teamed with Kline in Ang Lee's mood piece "The Ice Storm"
Reprised her role as Ripley in James Cameron's "Aliens"; earned an Oscar nomination for Best Actress
Made a cameo as The Director in the horror thriller "The Cabin in the Woods"
Starred in the USA Network miniseries "Political Animals" as a former First Lady-turned-Secretary of State
Co-starred in the action-drama "Chappie"
Played herself in the Pixar animated film "Finding Dory"
Appeared in the 2016 reboot of "Ghostbusters"
Voiced the Ship's Computer in Pixar hit "WALL·E"
Reprised role of Ellen Ripley in as-yet-untitled Neil Blomkamp "Alien" sequel