Appeared in several nationally broadcast commercials
Made TV debut alongside siblings as regular cast member on Fox's comedy variety series "In Living Color"
Made feature debut opposite brother Damon Wayans in "Mo' Money"
Featured in basketball drama "Above the Rim"
Co-created and co-starred with brother Shawn on sitcom "The Wayans Bros." (The WB)
First produced feature, "Don't Be a Menace to South Central While Drinking Your Juice in the Hood"; also co-wrote and starred
Played lead in comedy "Senseless"
Co-wrote and co-starred as stoner Shorty Meeks in box-office hit "Scary Movie"
Offered a dramatic turn as a drug user in Darren Aronofsky's "Requiem for a Dream"
Again portrayed Shorty Meeks
in "Scary Movie 2"
Joined Tom Hanks for the Coen brothers' remake of "The Ladykillers"
Co-wrote and co-starred with brother Shawn as FBI agents that go undercover as hotel heiresses in "White Chicks," directed by brother Keenen Ivory Wayans
Co-created (with Keenen and Shawn) the Nickelodeon animated series "Thugaboo"
Co-wrote and co-starred with brother Shawn in comedy "Little Man"; directed by Keenen
Featured in Eddie Murphy comedy vehicle "Norbit"
Co-produced and co-wrote "Dance Flick" with brothers; directed by nephew Damien Dante Wayans
Cast as Ripcord in big-screen version of "G.I. Joe: The Rise of Cobra"
Starred in paranormal genre spoof "A Haunted House"; also co-wrote with Rick Alvarez