Acted opposite Steve Martin in the comedy "The Man with Two Brains"
Made TV-movie debut in "Friends at Last" (CBS)
Re-teamed with Hurt and Kasdan for "The Accidental Tourist"
Returned to London, making her West End debut as Mrs. Robinson in a stage version of "The Graduate"; reprised role in Broadway production in 2002
TV debut on the NBC soap opera "The Doctors" as Nola Dancy Aldrich, a poor girl who married well
Appeared as TV anchorwoman Brenda Whitlass in TNT's satirical "Legalese"
Had supporting role in "Moonlight Over Valentino"
Narrated the documentary compilation, "Dear America: Letters Home from Vietnam"
Played hit-woman to Jack Nicholson's hit-man in John Huston's "Prizzi's Honor"
Returned to the Broadway stage as Maggie in "Cat on a Hot Tin Roof"; received a Best Actress Tony nomination; also hosted the annual telecast of the Tony Awards
Broadway debut in "Gemini"
Co-starred in the Broadway production of "Indiscretions"; was only cast member of five not nominated for a Tony Award
Joined the cast of Showtime's "Californication" as Charlie Runkle's (Evan Handler) sexually hyperactive boss
Portrayed a business woman turned prostitute in Ken Russell's "Crimes of Passion"
Re-teamed with Douglas and DeVito to reprise Joan Wilder in the sequel "The Jewel of the Nile"
Third film with Douglas and DeVito, the black comedy "The War of the Roses"; helmed by DeVito
Voiced a creepy-looking house in the animated feature "Monster House"
Directorial debut with the 30-minute Showtime film "Leslie's Folly" (for the series "Directed By")
Made London stage debut in "Our Betters"
Moved to NYC; within a month landed an agent; within four months had a part in an Off-Broadway play, "Mr T"
Played the comic villain in "Baby Geniuses"
Portrayed the title role of private investigator "V.I. Warshawski"
Returned to the theater in title role of "Camille" at the Long Wharf Theater in New Haven, Connecticut
Cast in the role of Sister Jamison Connelly in Matthew Lombardo's drama "High" at Hartford TheaterWorks; production transferred to Broadway in 2011
Provided the voice of Jessica Rabbit for the animated feature comedy, "Who Framed Roger Rabbit"; later voiced Jessica in the animated shorts "Tummy Trouble" (1989), "Rollercoaster Rabbit" (1990) and "Trail Mix-Up" (1993)
Had breakthrough screen role as Matty Walker opposite William Hurt in her debut feature, Lawrence Kasdan's "Body Heat"
Earned Best Actress Oscar nomination playing a middle-aged woman who finds herself reliving her teenage years in "Peggy Sue Got Married"; helmed by Francis Ford Coppola
First role opposite Michael Douglas, "Romancing the Stone" as fiction writer Joan Wilder; also first film with Danny DeVito
Played the title role in John Waters' "Serial Mom"
Returned to Broadway to star as Martha in "Who's Afraid of Virginia Woolf?"; earned a Tony nomination for her role
Stage-directing debut, "Crimes Of The Heart" at the Williamstown Theater Festival in Massachusetts; moved to off-Broadway in 2008
Portrayed the stern and dowdy mother of five daughters in "The Virgin Suicides"; directed by Sofia Coppola
Starred in the independent comedy-drama "The Perfect Family"
Appeared in "Dumb and Dumber To"
Began appearing on the series "The Path"