Acted with Green Mountain Guild, a traveling theater company in Vermont
Appeared with the Yale student repertory company in the Stephen Sondheim-Burt Shevelove musical, "The Frogs"
Appeared in the double bill "27 Wagons Full of Cotton" and "A Memory of Two Mondays"; received a Tony nomination as Featured Actress in a Play for the former
Appeared in the Central Park productions of "Henry V" and "Measure for Measure"
Made TV acting debut, reprising her stage role in the PBS "Theater in America" production of "Secret Service"
Made TV-movie debut as the wife of a professional hockey player accused of manslaughter in "The Deadliest Season" (CBS)
Cast opposite Jack Nicholson in "Heartburn"; second collaboration with Nichols
Re-teamed with Jack Nicholson for "Ironweed"
Played first comedic role in "She-Devil" opposite Roseanne Barr
Co-starred with Shirley MacLaine in "Postcards from the Edge," a screen adaptation of Carrie Fisher's semi-autobiographical novel; third collaboration with Mike Nichols
Played first role as an action heroine in "The River Wild"
Co-starred with Diane Keaton and Leonardo DiCaprio in "Marvin's Room"
Debut as executive producer (also starred) with her first TV-movie in eighteen years, "...First Do No Harm"
Earned eleveth Academy Award nomination for her role in "One True Thing"
Featured in the ensemble drama "Dancing at Lughnasa"; adapted from Brian Friel's award-winning play
Portrayed NYC violin teacher Roberta Guaspari-Tzavaras in "Music of the Heart"; required her to learn to play the violin.
Returned to the stage to star in the New York Shakespeare Festival production of "The Seagull"; staged by Mike Nichols
Cast as Clarissa Vaughn in the film adaptation of the Pulitzer-winning novel "The Hours"; received a Golden Globe nomination
Cast as Aunt Josephine opposite Jim Carrey in "Lemony Snicket's A Series of Unfortunate Events," based on the books by Daniel Handler
Played a psychoanalyst who discovers that her client (Uma Thurman) is dating her son in "Prime"
Cast in Robert Altman's adaptation of Garrison Keillor's "A Prairie Home Companion"
Cast in Michael Cunningham's film adaptation of Susan Minot's novel "Evening"; also starring her daughter, Mamie Gummer as a younger version of herself
Portrayed a TV journalist in the Robert Redford directed drama "Lions for Lambs"
Portrayed Sister Aloysius Beauvier in the film adaptation of John Patrick Shanley's play "Doubt"; earned Golden Globe and Academy Award nominations for Best Actress
Co-starred with Alec Baldwin in the comedy film "It's Complicated"; earned a Golden Globe nomination for Best Actress
Began recurring role as Camilla Bowner on comedy webseries "Web Therapy," starring Lisa Kudrow.
Portrayed former U.K. prime minister Margaret Thatcher in "The Iron Lady"
Co-starred with Tommy Lee Jones as a couple trying to bring some spark back to their marriage in "Hope Springs"
Starred as matriarch Violet Weston in the film adaption of Tracy Letts' stage hit "August: Osage County"
Co-starred as the Chief Elder in Young Adult fantasy "The Giver"
Co-starred in western drama "The Homesman," co-written and directed by Tommy Lee Jones
Starred as a faded rock star in Jonathan Demme's "Ricki and the Flash"