Appeared with the Yale student repertory company in the Stephen Sondheim-Burt Shevelove musical, "The Frogs"
Cast in Michael Cunningham's film adaptation of Susan Minot's novel "Evening"; also starring her daughter, Mamie Gummer as a younger version of herself
Earned eleveth Academy Award nomination for her role in "One True Thing"
Portrayed NYC violin teacher Roberta Guaspari-Tzavaras in "Music of the Heart"; required her to learn to play the violin.
Portrayed Sister Aloysius Beauvier in the film adaptation of John Patrick Shanley's play "Doubt"; earned Golden Globe and Academy Award nominations for Best Actress
Made TV acting debut, reprising her stage role in the PBS "Theater in America" production of "Secret Service"
Co-starred with Alec Baldwin in the comedy film "It's Complicated"; earned a Golden Globe nomination for Best Actress
Debut as executive producer (also starred) with her first TV-movie in eighteen years, "...First Do No Harm"
Featured in the ensemble drama "Dancing at Lughnasa"; adapted from Brian Friel's award-winning play
Portrayed a TV journalist in the Robert Redford directed drama "Lions for Lambs"
Re-teamed with Jack Nicholson for "Ironweed"
Returned to the stage to star in the New York Shakespeare Festival production of "The Seagull"; staged by Mike Nichols
Made TV-movie debut as the wife of a professional hockey player accused of manslaughter in "The Deadliest Season" (CBS)
Appeared in the Central Park productions of "Henry V" and "Measure for Measure"
Appeared in the double bill "27 Wagons Full of Cotton" and "A Memory of Two Mondays"; received a Tony nomination as Featured Actress in a Play for the former
Cast as Clarissa Vaughn in the film adaptation of the Pulitzer-winning novel "The Hours"; received a Golden Globe nomination
Cast in Robert Altman's adaptation of Garrison Keillor's "A Prairie Home Companion"
Co-starred with Diane Keaton and Leonardo DiCaprio in "Marvin's Room"
Played first comedic role in "She-Devil" opposite Roseanne Barr
Played first role as an action heroine in "The River Wild"
Played a psychoanalyst who discovers that her client (Uma Thurman) is dating her son in "Prime"
Acted with Green Mountain Guild, a traveling theater company in Vermont
Cast as Aunt Josephine opposite Jim Carrey in "Lemony Snicket's A Series of Unfortunate Events," based on the books by Daniel Handler
Cast opposite Jack Nicholson in "Heartburn"; second collaboration with Nichols
Co-starred with Shirley MacLaine in "Postcards from the Edge," a screen adaptation of Carrie Fisher's semi-autobiographical novel; third collaboration with Mike Nichols
Portrayed former U.K. prime minister Margaret Thatcher in "The Iron Lady"
Co-starred with Tommy Lee Jones as a couple trying to bring some spark back to their marriage in "Hope Springs"
Began recurring role as Camilla Bowner on comedy webseries "Web Therapy," starring Lisa Kudrow.
Starred as matriarch Violet Weston in the film adaption of Tracy Letts' stage hit "August: Osage County"
Co-starred as the Chief Elder in Young Adult fantasy "The Giver"
Co-starred in western drama "The Homesman," co-written and directed by Tommy Lee Jones
Starred as a faded rock star in Jonathan Demme's "Ricki and the Flash"
Voiced Mr. Fox's (George Clooney) wife in Wes Anderson's animated adaptation of the Roald Dahl book "Fantastic Mr. Fox"
Earned first Oscar nomination for her supporting role in "The Deer Hunter"
Portrayed famed chef Julia Child in Nora Ephron's "Julie & Julia"; earned SAG and Oscar nominations for Best Actress
Cast in the Woody Allen film "Manhattan" as Allen's ex-wife
Made film debut in "Julia" opposite Jane Fonda and Vanessa Redgrave
Cast as the all-powerful magazine editor Miranda Priestley in the fashionista comedy "The Devil Wears Prada," based on Lauren Weisberger's best-selling novel; earned SAG and Oscar nominations for Best Actress
Earned second Academy Award for her portrayal of a Polish concentration camp survivor in "Sophie's Choice"
Performed first starring role in "The French Lieutenant's Woman"
Played author Isak Dinesen in Sydney Pollack's lavish biopic "Out of Africa"
Received strong reviews and an Oscar nomination for "Silkwood"; first film with Mike Nichols
Starred as author Susan Orlean in the film "Adaptation"; loosely based on Orlean's book <i>The Orchard Thief</i>; received an Academy Award nomination for a supporting role
Starred in the film version of the ABBA musical "Mamma Mia!"; earned a Golden Globe nomination for Best Actress in a Musical and a Grammy nomination for the soundtrack
Portrayed Lindy Chamberlain, a religious Australian woman accused of murdering her own child in "A Cry in the Dark (Evil Angels)"; received an Academy Award nomination for Best Actress
Received tenth Academy Award nomination as an Italian-born Midwestern woman who has a brief affair with a photographer (Clint Eastwood) in "The Bridges of Madison County," also directed by Eastwood
Won an Emmy for her starring role as a Catholic married to a Jewish man in the NBC miniseries "Holocaust"
Debuted on Broadway in "Trelawny of the Wells" at Lincoln Center's Vivian Beaumont Theater
Cast as an aging actress who trades her soul for a youthful appearance in the black comedy "Death Becomes Her"
Featured with Denzel Washington in "The Manchurian Candidate" directed by Jonathan Demme; received a Golden Globe nomination for Best Supporting Actress
Portrayed Hannah Pitt in the HBO miniseries adaptation of Tony Kushner's "Angels in America"; fourth collaboration with Mike Nichols
Made professional acting debut in NYC in "The Playboy of Seville" at the Cubiculo Theatre
Won first Academy Award for her portrayal of a dissatisfied wife and mother in "Kramer vs. Kramer"
Starred as The Witch in Rob Marshall's screen adaptation of Stephen Sondheim's "Into the Woods."
Co-starred as Emmeline Pankhurst in Sarah Gavron's historical drama "Suffragette"
Played the title role in "Florence Foster Jenkins"