Stage acting debut in Boy Scout play
Joined director Joshua Logan's University Players in Falmouth, Massachusetts, acting with future film co-stars Margaret Sullavan and Henry Fonda
Professional stage acting debut in "Goodbye Again" with University Players in Cape Cod; also in play when it moved to Broadway
Moved to NYC with roommate Henry Fonda; Broadway acting debut in "Carrie Nation"
Moved to Hollywood; film debut (walk-on part) in "Art Trouble"
Film acting debut, "The Murder Man"
First lead in an 'A' budget motion picture, "Born to Dance", a musical starring Eleanor Powell
Made first of three films with director Frank Capra, "You Can't Take It With You"
First Western, "Destry Rides Again"
Garnered first Oscar nomination for "Mr. Smith Goes to Washington"
Turned in Academy Award-winning turn as a reporter covering a society wedding in "The Philadelphia Story"
Last film before war service, "Ziegfeld Girl"
Became first Hollywood screen actor drafted into US Army (March 22)
Was a bomber pilot during WWII; achieved rank of full colonel
Replaced Frank Fay in Broadway run of "Harvey" in the late 1940s
First film after WWII service, "It's a Wonderful Life", his last film with Capra; received third Academy Award nomination as Best Actor
First of four films with director Alfred Hitchcock, "Rope"
Appeared in many Westerns during the 1950s and 1960s, beginning with such films as "Broken Arrow" (1950)
Made first of eight films with director Anthony Mann, "Winchester '73"
Starred in film version of hit Broadway play "Harvey"; received Oscar nomination as Best Actor
Cast as Buttons the Clown in Cecil B, DeMille's "The Greatest Show on Earth"
Reunited with Hitchcock for "Rear Window"
Had title role in the biopic "The Glenn Miller Story", directed by Anthony Mann
Co-starred with Doris Day in Hitchcock's remake of "The Man Who Knew Too Much"
Portrayed Charles Lindberg in "The Spirit of St. Louis", helmed by Billy Wilder
Last film with Alfred Hitchcock, "Vertigo"
Garnered fifth and final Best Actor Academy Award nomination for work as a lawyer in "Anatomy of a Murder"
First worked with director John Ford in "Two Rode Together"
Had co-starring role in "How the West Was Won"
Starred with John Wayne in "The Man Who Shot Liberty Valance"
Last film with Ford, "Cheyenne Autumn"
Retired from military reserve service with the rank of brigadier general
Returned to Broadway in revival of "Harvey"
Starred in NBC series, "The Jimmy Stewart Show"
Returned to series TV as a detective in the CBS drama "Hawkins"
London stage debut, "Harvey"
Final feature acting role, the grandfather in "The Magic of Lassie"
Teamed with Bette Davis in the HBO original "Right to Die"
Had last TV acting role in the ABC miniseries "North and South: Book II"