Born and raised in Arkansas
Moved to NYC and sold books at Doubleday's while attending the first-year program at the Neighborhood Playhouse
Invited to return for the second year program; eliminated her thick Southern accent
Co-founded (with four other Playhouse graduates) and acted with Cracked Tokens, an improvisational comedy troupe
Performed with Cracked Tokens for the NYC Bureau of Alcoholism
Made film debut in Jack Nicholson's western, "Goin' South"
First leading role in a feature, "Time After Time" playing a modern woman who falls in love with author H.G. Wells (played by husband-to-be Malcolm McDowell)
Won an Academy Award for her performance in Jonathan Demme's "Melvin and Howard" as the wife of a man who claims to have befriended reclusive billionaire Howard Hughes
Featured in Woody Allen's "A Midsummer Night's Sex Comedy"
TV debut, playing the lead in the Showtime adaptation of F. Scott Fitzgerald's "Tender Is the Night"
Made London stage debut in Lindsay Anderson's "Holiday"
Earned an Emmy nomination for her role in the CBS movie "The Attic: The Hiding of Anne Frank"
Executive producing debut, "End of the Line"; also co-starred
Played Steve Martin's wife in the Ron Howard directed "Parenthood"
Played Clara Clayton, Doc's love interest, in Robert Zemeckis' "Back to the Future Part III"
Provided the voice of Clara Clayton for the CBS Saturday morning cartoon "Back to the Future: The Animated Series"
Made Broadway stage debut in the title role of "Candida"
Played an adulterous wife, having an affair with Johnny Depp in Lasse Hallström's "What's Eating Gilbert Grape?"
Made Los Angeles stage debut in "Marvin's Room"
Portrayed the mother of Richard Nixon in the Oliver Stone biopic "Nixon"
Played the wife of the title character, opposite husband Ted Danson in the NBC miniseries, "Gulliver's Travels"
Cast opposite real-life husband Ted Danson in the CBS sitcom "Ink"
Returned to the NYC stage in "The Beginning of August"
Appeared several times opposite real life husband, Ted Danson on Larry David's "Curb Your Enthusiasm" (HBO)
Featured in the drama, "Life as a House" starring Kevin Kline
Joined the ensemble cast of "Sunshine State" written and directed by John Sayles
Played the wife of James Caan in the Jon Favreau comedy "Elf"
Cast as the title character's mother in the CBS drama "Joan of Arcadia"
Played the title role in Randall Miller's "Marilyn Hotchkiss Ballroom Dancing and Charm School"
Co-starred with Jodie Foster in the crime drama, "The Brave One"
Cast as Will Ferrell's mother in the comedy "Step Brothers"
Played Ryan Reynolds' mother in the comedy "The Proposal"