Performed Abbott-and-Costello-style comic sketches with his father at the Hollywood Canteen
Made theatrical debut at age 17, starring in "Charley's Aunt" in summer stock in Barnesville, PA
While in Europe studying abroad, performed with father on stage in the Rome production of "Room Service"
Made New York stage debut as an understudy in "The Hot Corner"
Co-starred in "Purlie Victorious" on Broadway
Film acting debut in "Gone Are the Days"; repeating his role from the Broadway production "Purlie Victorious"
Appeared in the Broadway play "Fair Game for Lovers"
First leading role on Broadway in "The Owl and the Pussycat"
Cast as a series regular on the NBC political and social satire program "That Was the Week That Was"
Starred in the Broadway musical "The Apple Tree"; earned a Tony Award nomination
Portrayed George Plimpton in the biopic "Paper Lion"
TV-movie debut in "The Glass House" (ABC)
Breakthrough role of Capt. Benjamin Franklin 'Hawkeye' Pierce in the TV adaptation of the 1970 film "M*A*S*H" (CBS); wrote 13 episodes and directed 32, including the show's 1983 two-and-a-half hour series finale "Goodbye, Farewell, and Amen"; earned 25 Emmy nominations for acting, writing and directing and 11 Golden Globe nominations
Co-directed and co-starred (with Carol Burnett) in the TV adaptation of the Broadway comedy "6 Rms Riv Vu" (CBS); earned an Emmy nomination for Best Actor
Created and wrote pilot for the CBS sitcom "We'll Get By"; also executive produced
Portrayed convicted killer Caryl Chessman in the NBC TV-movie "Kill Me If You Can"; earned an Emmy nomination
Teamed with Ellen Burstyn in Robert Mulligan's feature adaptation of "Same Time, Next Year"
Feature screenwriting debut, "The Seduction of Joe Tynan"; also starred as the titular politician
Feature directing debut (also scripted) the ensemble "The Four Seasons"; again collaborated with Burnett who played his onscreen spouse
Executive produced the short-lived CBS sitcom "The Four Seasons" based film; also appeared in pilot
Directed and wrote second film, "Sweet Liberty"
Helmed third film (also wrote and starred), "A New Life"
Received critical acclaim for the role of an egotistical director in Woody Allen's "Crimes and Misdemeanors"
Wrote and directed "Betsey's Wedding"; also co-starred
Made London stage debut as the Stage Manager in Thornton Wilder's "Our Town"
Returned to Broadway as star of Neil Simon's play "Jake's Women"
Portrayed scientist Robert Gallo in the acclaimed TV-movie "And the Band Played On" (HBO); received Emmy nomination
Hosted the PBS series "Scientific American Frontiers"
Teamed again with Woody Allen for "Manhattan Murder Mystery"
Offered an uncharacteristically nasty turn in the based-on-fact drama "White Mile" (HBO)
Reprised stage role in CBS TV adaptation of "Neil Simon's 'Jake's Women'"
Made third film with Woody Allen, the romantic musical comedy "Everyone Says I Love You"
Appeared in Costa-Gavras' "Mad City" opposite Dustin Hoffman and John Travolta
Played Jennifer Aniston's brother-in-law in "The Object of My Affection"
Returned to Broadway, co-starring with Alfred Molina and Victor Garber in "Art"
Had a recurring role on NBC's "ER" as a prominent surgeon in the early stages of Alzheimer's disease; earned an Emmy nomination for Outstanding Guest Actor
Played lead role of physicist Richard Feynman in the L.A. stage production of "Q.E.D."; reprised role in NYC
Received 30th career Emmy nomination for the Showtime movie "Club Land"
Portrayed defense attorney Ernie Goodman in the Showtime original movie "The Killing Yard"
Cast as Senator Ralph Owen Brewster in Martin Scorsese's "The Aviator" based on the life of legendary director and aviator Howard Hughes; earned an Oscar nomination for Best Supporting Actor
Joined the cast of NBC's White House drama "The West Wing" playing a Republican from California with presidential aspirations; earned Emmy (2005) and SAG (2006) nominations for Best Supporting Actor in a Drama Series
Starred in Joe Mantello's revival of David Mamet's play "Glengarry Glen Ross"; earned a Tony nomination for his role
Published his memoir <i>Never Have Your Dog Stuffed: And Other Things I've Learned</i>
Co-starred in the boxing film "Resurrecting the Champ"
Earned an Emmy nomination for his guest starring role on NBC's "30 Rock" as Milton Greene, Jack's biological father
Guest starred on Showtime's "The Big C"
Teamed with Ben Stiller and Eddie Murphy in the ensemble comedy "Tower Heist"
Re-teamed with "The Object of My Affection" co-stars Jennifer Aniston and Paul Rudd in "Wanderlust"