Cast in the thriller "Taking Lives"
Co-starred in daughter Zoe Cassavetes' directorial debut "Broken English"
Born and raised in Wisconsin
Cast as Julia Roberts' mother in "Something to Talk About"
First TV-movie, played lesbian fighting for custody of her children in "A Question of Love" (ABC)
Moved to NYC to attend AADA
Offered a nuanced turn as a troubled actress in "Opening Night"; film only released for Oscar consideration in L.A.; screened at the New York Film Festival in 1988; released theatrically in 1991
Picked up second Emmy Award as a Manhattan socialite who befriends a homeless woman in the CBS TV-movie "Face of a Stranger"
Starred as Sandra Bullock's mother in "Hope Floats"
Teamed with Bette Davis, playing Davis' estranged daughter in the CBS drama "Strangers: The Story of a Mother and a Daughter"
Won acclaim for her role in Cassavetes' "Faces"
Again directed by son in "She's So Lovely," a previously un-produced screenplay by John Cassavetes
Appeared in the ensemble drama "Playing by Heart"
Played a cab passenger driven by Winona Ryder in Jim Jarmusch's "Night on Earth"
Starred in Woody Allen's "Another Woman" as sheltered woman forced to confront her life choices
Worked off-Broadway at the Provincetown Playhouse and in stock
Acted in "Hysterical Blindness" (HBO); screened at Sundance; received a Golden Globe nomination for Best Supporting Actress
Acted opposite Cassavetes in Paul Mazursky's "Tempest," a loose re-working of Shakespeare's play
Appeared in off-Broadway production of "Dangerous Corner"
Made Broadway debut as understudy for the role of The Girl in "The Seven Year Itch"; later assumed part
Cast as the mother of an AIDS-stricken lawyer in "An Early Frost"; received first Emmy nomination
Co-starred with Diane Lane in the TV version of the stage play "Grace & Glorie" (CBS)
Earned fourth career Emmy nomination playing a Southern grandmother in "The Color of Love: Jacey's Story" (CBS)
Featured as Adrienne Van Leyden on ABC nighttime soap opera "Peyton Place"
First collaboration with Cassavetes as director, "A Child Is Waiting"
Had featured role in "The Mighty"
Picked up second Best Actress Oscar nomination as a gun moll in "Gloria"
Played Brooke Shields' overbearing mother in the independent film "The Weekend"
Starred on Broadway in "Middle of the Night" with Edward G. Robinson
Starred opposite Kate Hudson in the supernatural thriller the "Skeleton Key"
Starred opposite Peter Falk in Cassavetes' "A Woman Under the Influence"; earned Best Actress Oscar nomination
Was mistress of ceremonies in "All About Love" at the Versailles Night Club Theatre in Manhattan
Won scholarship to study at Jarvis Repertory Theatre in Washington, DC
Made debut as TV regular on the syndicated series "Top Secret USA"
Delivered a fine turn as the eccentric Southern aunt of a young boy in "The Neon Bible"
Directed by son Nick Cassavetes in "Unhook the Stars"; won critical praise as a widow who befriends her neighbor's son
Earned an Emmy nomination for her guest starring role as a moderately compulsive surrogate mother to the main character on an episode of "Monk" (USA Network)
Film acting debut, "The High Cost of Loving"
Last feature collaboration with Cassavetes, "Love Streams"
Played regular role on "87th Precinct" (NBC)
Portrayed a terminally ill woman in the Lifetime original movie "What if God Were the Sun?"; earned Emmy and SAG nominations for Best Actress in a Miniseries or TV Movie
Starred opposite James Garner in "The Notebook," directed by son Nick Cassavetes
Won an Emmy for her portrayal of the former First Lady in the ABC biopic "The Betty Ford Story"