Stage debut at age eight in "The Haggadah" at New York Public Theater
Made film acting debut in a bit part in "Rollover"
Appeared in a Calvin Klein jeans commercial at age 11
TV acting debut, "The Hand-Me-Down Kid"
First substantial film role, "The River Rat"
Breakthrough performance as Stef Steinbrenner in "The Goonies"
Critically lauded performance as the Reverend Spellgood's daughter in "The Mosquito Coast" starring Harrison Ford and her future real-life love interest, River Phoenix
Co-starred in the critically praised but commercially unsuccessful feature, "Shy People"
Second film with River Phoenix, the Academy Award-nominated film, "Running on Empty"
Played the indignant teenage daughter of Dianne Wiest in "Parenthood"
Co-starred with Campbell Scott in Shakespeare's "Pericles, Prince of Tyre" at the Public Theater
First feature starring role, "Samantha"
Portrayed the lesbian lover of radical feminist Valerie Solanas in the indie film "I Shot Andy Warhol"
Appeared in "The Defenders: Payback", the first of a projected series of TV-movies for Showtime
Won praise for leading role in "Eye of God"
Donned a dark wig to play Edward Furlong's sister in John Waters' "Pecker"
Appeared in the ensemble film "200 Cigarettes"
Had a recurring role in the television drama "ER" (NBC) as Meg Corwyn
Starred in a Chicago stage production of "Hedda Gabler"
Made stage directorial debut with "Absolution," performed at Chicago's Steppenwolf Theatre Company
Nominated for an Emmy Award for her guest appearance on the television drama "Law & Order: Special Victims Unit" (NBC)
Guest-starred on an episode of "7th Heaven" (WB); also received her first writing credit for a different episode that year entitled "Red Socks"
Cast in the play "The Coast of Utopia," a trilogy by Tom Stoppard; earned a Tony award nomination
Formed a production company called, Everything is Horrible; produced a number of short films for the internet
Appeared in the Broadway play, "Top Girls"; received a Tony award nomination for Featured Actress in a Play
Earned her third consecutive Tony nomination for her role in "Pal Joey"
Performed a one-woman show called "Martha Plimpton Sings?"
Returned to TV to star in the FOX comedy "Raising Hope"
Nominated for the 2011 Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series