Grew up in Arizona, Tennessee, Texas, Thailand, Germany and France where her father served in the US Army
Played a recurring role in the ABC daytime drama "Ryan's Hope"
Appeared in regional theater productions of "The Night of the Iguana" and "The Little Foxes"
Off-off-Broadway debut, "The Girl in Pink" at the Quaigh Theatre
TV-movie debut, "Too Young the Hero" (CBS)
Off-Broadway debut, "The Art of Success"
Film debut, "Signs of Life"
Played a neighbor helping her gay friend through the early years of the AIDS crisis in Norman Rene's "Longtime Companion"
Broadway debut in Craig Lucas' "Prelude to a Kiss" (originated the role at the Berkeley Repertory Theatre); earned a Tony nomination as Actress in a Play
First starring role in a feature, "Fried Green Tomatoes"
Portrayed Dee, a secretary and part-time lover of Kevin Kline, in Lawrence Kasdan's "Grand Canyon"
Acted Off-Broadway in John Patrick Shanley's Hollywood satire "Four Dogs and a Bone"
Played John Cusack's girlfriend in Woody Allen's "Bullets Over Broadway"
First appearance in a Hallmark Hall of Fame production, "A Place for Annie" (ABC) as a surly AIDS patient who tries to get back the baby she abandoned
Delivered a poignant portrayal of a woman dying from AIDS in "Boys on the Side"
Portrayed a parapalegic deaf mute in the feature "Reckless"; film is based on the play by Craig Lucas
Starred opposite John Turturro as singer Phyllis McGuire in HBO's "Sugartime"
Acted the part of Henrietta Stackpole in Jane Campion's "The Portrait of a Lady"; based on the novel by Henry James
Earned critical acclaim for her performance of a young girl molested by a relative in the Pulitzer Prize-winning play "How I Learned to Drive"; played character at various ages from teens to adulthood
Appeared in small but pivotal role as the free-spirited (and later suicidal) Lucy in the Hallmark Hall of Fame presentation of "Anne Tyler's 'Saint Maybe'" (CBS)
Returned to the NYC stage in the Off-Broadway production of Alan Ayckbourn's "Communicating Doors"
Co-starred in the Slamdance-screened "Let the Devil Wear Black"; a modern interpretation of Shakespeare's Hamlet written and directed by Stacey Title
Portrayed a cake maker who problematically lacks a sense of taste in the Canadian-made "The Five Senses"
Played an unhappy young woman who finds purpose in a new romance in the Hallmark Hall of Fame presentation "Cupid & Cate" (CBS)
Garnered rave reviews for performance in the Off-Broadway play "Proof"; production moved to Broadway in the fall
Had recurring role on the NBC series "The West Wing"; reprised her role as women's-rights advocate Amy Gardner for the shows final episodes in 2006; received an Emmy (2002) nomination for Best Supporting Actress in a Drama and a SAG (2003) nomination for Best Ensemble
Portrayed Molly Graham in the thriller feature "Red Dragon" the prequel to "Silence of the Lambs"
Cast as Harper Pitt in the HBO adaptation of "Angels in America"; received a SAG nomination for Best Supporting Actress in a Television Movie or Miniseries (2004)
Starred in the dark comedy "Saved!" with Jena Malone and Mandy Moore
Starred on Broadway in the revival of Craig Lucas's "Reckless"; received a Tony nomination for her role
Cast in the Showtime series "Weeds" as a suburban mom who beings dealing Marijuana, after her husband's unexpected death; earned SAG (2006, 2007, 2008, 2009), Golden Globe (2007, 2008, 2009) and Emmy (2007, 2008, 2009) nominations for Best Actress in a Comedy Series
Cast in John Turturro's big-screen musical "Romance and Cigarettes"; film released theatrically in 2007
Starred in Oxygen's "The Robber Bride" as Zenia, a glamorous femme fatale; earned an Emmy nomination for Best Actress in a Miniseries or Movie
Played Jesse's (Brad Pitt) wife, Zee James in "The Assassination of Jesse James by the Coward Robert Ford"
Cast as the mother in the fantasy film "The Spiderwick Chronicles"
Appeared in the off-Broadway play "Dead Man's Cell Phone" at Playwrights Horizons theater
Starred in the Broadway revival of Henrik Ibsen's "Hedda Gabler"
Nominated for the 2009 Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series
Played Sarah opposite Bruce Willis in "Red," an adaption of the comic book mini-series of the same name
Appeared in both "R.I.P.D." and "Red 2," two big-budget movies that both debuted on the same day in July of that year