Acted Off-Broadway in John Patrick Shanley's Hollywood satire "Four Dogs and a Bone"
Acted the part of Henrietta Stackpole in Jane Campion's "The Portrait of a Lady"; based on the novel by Henry James
Appeared in regional theater productions of "The Night of the Iguana" and "The Little Foxes"
Co-starred in the Slamdance-screened "Let the Devil Wear Black"; a modern interpretation of Shakespeare's Hamlet written and directed by Stacey Title
First appearance in a Hallmark Hall of Fame production, "A Place for Annie" (ABC) as a surly AIDS patient who tries to get back the baby she abandoned
Played a recurring role in the ABC daytime drama "Ryan's Hope"
Played an unhappy young woman who finds purpose in a new romance in the Hallmark Hall of Fame presentation "Cupid & Cate" (CBS)
Portrayed a cake maker who problematically lacks a sense of taste in the Canadian-made "The Five Senses"
Portrayed Dee, a secretary and part-time lover of Kevin Kline, in Lawrence Kasdan's "Grand Canyon"
Starred in Oxygen's "The Robber Bride" as Zenia, a glamorous femme fatale; earned an Emmy nomination for Best Actress in a Miniseries or Movie
Starred in the dark comedy "Saved!" with Jena Malone and Mandy Moore
TV-movie debut, "Too Young the Hero" (CBS)
Starred in the Broadway revival of Henrik Ibsen's "Hedda Gabler"
Appeared in the off-Broadway play "Dead Man's Cell Phone" at Playwrights Horizons theater
First starring role in a feature, "Fried Green Tomatoes"
Garnered rave reviews for performance in the Off-Broadway play "Proof"; production moved to Broadway in the fall
Nominated for the 2009 Primetime Emmy Award for Outstanding Lead Actress in a Comedy Series
Off-off-Broadway debut, "The Girl in Pink" at the Quaigh Theatre
Played a neighbor helping her gay friend through the early years of the AIDS crisis in Norman Rene's "Longtime Companion"
Returned to the NYC stage in the Off-Broadway production of Alan Ayckbourn's "Communicating Doors"
Starred on Broadway in the revival of Craig Lucas's "Reckless"; received a Tony nomination for her role
Broadway debut in Craig Lucas' "Prelude to a Kiss" (originated the role at the Berkeley Repertory Theatre); earned a Tony nomination as Actress in a Play
Cast as Harper Pitt in the HBO adaptation of "Angels in America"; received a SAG nomination for Best Supporting Actress in a Television Movie or Miniseries (2004)
Cast in John Turturro's big-screen musical "Romance and Cigarettes"; film released theatrically in 2007
Film debut, "Signs of Life"
Off-Broadway debut, "The Art of Success"
Played Jesse's (Brad Pitt) wife, Zee James in "The Assassination of Jesse James by the Coward Robert Ford"
Played John Cusack's girlfriend in Woody Allen's "Bullets Over Broadway"
Portrayed Molly Graham in the thriller feature "Red Dragon" the prequel to "Silence of the Lambs"
Starred opposite John Turturro as singer Phyllis McGuire in HBO's "Sugartime"
Appeared in small but pivotal role as the free-spirited (and later suicidal) Lucy in the Hallmark Hall of Fame presentation of "Anne Tyler's 'Saint Maybe'" (CBS)
Cast as the mother in the fantasy film "The Spiderwick Chronicles"
Cast in the Showtime series "Weeds" as a suburban mom who beings dealing Marijuana, after her husband's unexpected death; earned SAG (2006, 2007, 2008, 2009), Golden Globe (2007, 2008, 2009) and Emmy (2007, 2008, 2009) nominations for Best Actress in a Comedy Series
Delivered a poignant portrayal of a woman dying from AIDS in "Boys on the Side"
Earned critical acclaim for her performance of a young girl molested by a relative in the Pulitzer Prize-winning play "How I Learned to Drive"; played character at various ages from teens to adulthood
Grew up in Arizona, Tennessee, Texas, Thailand, Germany and France where her father served in the US Army
Had recurring role on the NBC series "The West Wing"; reprised her role as women's-rights advocate Amy Gardner for the shows final episodes in 2006; received an Emmy (2002) nomination for Best Supporting Actress in a Drama and a SAG (2003) nomination for Best Ensemble
Portrayed a parapalegic deaf mute in the feature "Reckless"; film is based on the play by Craig Lucas
Played Sarah opposite Bruce Willis in "Red," an adaption of the comic book mini-series of the same name
Appeared in both "R.I.P.D." and "Red 2," two big-budget movies that both debuted on the same day in July of that year