Made her stage debut as Glinda the Good Witch in a second grade production of "The Wizard of Oz"
Made professional debut as comedian at the local Ground Round restaurant's open-mike night at age 16
Made TV debut on the syndicated series "Star Search"; won the comedy competition five times by decade's end
Made TV series debut as Nell Carter's dental-hygenist neighbor on "Gimme a Break" (NBC)
Produced and hosted VH1's half-hour series "Stand Up Spotlight"
Starred on the short-lived Fox sitcom "Stand By Your Man"
Made feature acting debut in Penny Marshall's "A League of Their Own"
Played Meg Ryan's best buddy in "Sleepless in Seattle"
Joined Richard Dreyfuss and Emilio Estevez for the sequel "Another Stakeout"
Offered a bright performance in Garry Marshall's "Exit to Eden" as half of a team of undercover cops
Played Betty Rubble in the live-action feature version of "The Flintstones"
Made Broadway debut as Rizzo in a revival of the musical "Grease"
Delivered memorable role in Ted Demme's "Beautiful Girls"
Hosted the daily syndicated talk show "The Rosie O'Donnell Show"; also served as executive producer
Served as host for the annual Tony Awards telecast on CBS for two consecutive years
Portrayed a baseball-loving nun in M. Night Shyamalan's "Wide Awake"
Hosted "The 42nd Annual Grammy Awards"
Supplied the voice of Terkoz for Disney's animated "Tarzan"
Became the editorial director of <i>McCall's</i> magazine; retitled it <i>Rosie</i> in 2001; ceased publication at the end of 2002
Assumed role of the Cat in the Hat in the Broadway musical "Seussical" while originator David Shiner was on vacation
Narrated the Oscar-nominated documentary "Artists and Orphans: A True Drama"
Played a lesbian on an episode of "Will & Grace" (NBC) only a month before she officially 'came out'
Published her memoir <i>Find Me</i>
Resigned from daytime television and returned to doing stand-up
Severed her connection with Gruner & Jahr USA Publishing and resigned from the <i>Rosie</i> Magazine
Co-starred as a developmentally disabled woman opposite Andie MacDowell in the CBS movie "Riding the Bus With My Sister"; directed by Anjelica Huston
Cast in the role of Golde, the wife of Harvey Fierstein's 'Tevye the milkman' in the Broadway revival of the musical "Fiddler on the Roof"
Helmed the documentary film "Aboard: Rosie's Family Cruise," about R. Family Vacations, the gay cruise that was started by O'Donnell and her partner (aired on HBO)
Announced as the replacement for Meredith Viera on "The View" (ABC)
Returned to daytime TV as co-host of "The View" (ABC); left the show in 2007 and was replaced by Whoopi Goldberg
Released her second memoir <i>Celebrity Detox</i>
Hosted a daily radio show for Sirius XM Radio in the fall
Guest starred on the Lifetime series "Drop Dead Diva"
Announced return to television with her talk show "The Rosie Show" on Oprah Winfrey's eponymous cable network OWN; premiered in 2011 and cancelled after five-month run in March 2012 due to low ratings