Made TV debut at the age of 12 on the ABC Afterschool Special "The Seven Wishes of a Rich Kid"
Feature debut in "Little Darlings" playing Sunshine Walker, the daughter of hippie parents
Broadway debut as the bratty Dinah Lord in the revival of "The Philadelphia Story"
Appeared in Sidney Lumet's "Prince of the City"
TV-movie debut, "My Body, My Child" (ABC) playing Vanessa Redgrave's daughter
Played the daughter of Jeremy Irons and Christine Baranski in the Broadway production of Tom Stoppard's "The Real Thing"; also simultaneously appeared in David Rabe's "Hurlyburly"; both directed by Mike Nichols
Portrayed Mozart's maid in Milos Forman's "Amadeus"
Played the daughter of a presidential candidate in Robert Altman's episodic political satire "Tanner '88" (HBO)
Acted in the workshop production of "The Heidi Chronicles"; played several characters when it came to Broadway in 1989
Had featured role as Heather in "Addams Family Values"
Replaced Marcia Gay Harden as Harper Pitt, the pill-popping Mormon wife whose husband reveals his homosexuality in Tony Kushner's two-part theatrical epic "Angels in America: Millennium Approaches" and "Angels in America: Perestroika"
Received a Tony nomination for her role as the headstrong young woman who falls for a mama's boy in "Indiscretions"
Founding member of the theatrical troupe The Drama Dept. with Sarah Jessica Parker, Dylan Baker, John Cameron Mitchell and Billy Crudup; acted in the group's productions of Tennessee Wiliams' "Kingdom on Earth" (1996), a revival of "June Moon" (1997) and "The Country Club" (1999)
Returned to Broadway, succeeding Jessica Hecht in the Tony Award-winning "The Last Night of Ballyhoo"
Landed breakthrough TV role as Miranda Hobbes, the no-nonsense lawyer on the HBO series "Sex and the City"; received Emmy (2002, 2003, 2005), Golden Globe (2000, 2001, 2003, 2004, 2006) and SAG (2006) nominations
Made cameo appearance as a participant in a Sexaholics Anonymous meeting in the remake of "The Out-of-Towners"
First leading role in a feature, as a video artist romanced by a bisexual actor in "Advice from a Caterpillar"
Appeared in the Broadway revival of "The Women"
Had a small part in the indie comedy "Igby Goes Down"
Reprised role in "Tanner on Tanner," the sequel to the HBO political satire "Tanner '88"
Portrayed Eleanor Roosevelt for HBO's "Warm Springs" opposite Kenneth Branagh as Franklin Roosevelt; received Emmy, Golden Globe and SAG nominations for the role
Won a Tony Award for her portrayal of a grieving mother in Broadway's "Rabbit Hole"
Performed the title role in the off-Broadway play "The Prime of Miss Jean Brodie"
Guest starred on an episode of NBC's "Law & Order: Special Victims Unit"
Reprised the character of Miranda Hobbes in the big screen adaptation "Sex and the City: The Movie"
Guest starred on Showtime's "The Big C" as the college roommate of Laura Linney's character
Returned as Miranda Hobbes for "Sex and the City 2"
Featured in the HBO movie "Too Big to Fail"
Cast in the crime drama "Rampart" opposite Woody Harrelson
Starred in the Broadway play "Wit"