Appeared off-Broadway in "Four Dogs and a Bone" and "The Naked Truth"
Starred as Mary Magdalene in the CBS miniseries "Jesus"
Starred as Stacey Colbert, a liberal journalist who enters into a marriage of convenience on the Fox sitcom "Ned and Stacey"
Starred with Dermot Mulroney in the romantic comedy "The Wedding Date"
Voiced forest ranger Beth in the animated comedy "Open Season"
Landed recurring role of scheming Dana Abandando on "NYPD Blue" (ABC)
Played the female lead in "McHale's Navy" opposite Tom Arnold
Cast as Ben Stiller's cheating wife in "Along Came Polly"
Cast in a small role as a journalist in Woody Allen's "Celebrity"
Featured in Diane English's female ensemble "The Women," a remake of the 1936 play by Clare Boothe Luce
Made a guest appearance as Jerry's unavailable crush on an episode of "Seinfeld" (NBC)
Cast opposite Richard Gere in "The Mothman Prophecies"
Replaced Sherilyn Fenn on the short-lived ABC series "Prey"
Voiced Arlene, Garfield's girlfriend in "Garfield: The Movie"
Cast in a supporting role opposite Eric Bana and Drew Barrymore in "Lucky You"
Executive produced and starred in the ABC comedy film "Wright vs. Wrong"
Co-starred as a songwriter and creator of a Broadway musical on NBC's "Smash"
Appeared opposite Woody Allen in "Hollywood Ending"
Feature film debut in "A Walk in the Clouds"
Gained attention of entertainment industry as Harper Pitt in student workshop production of "Angels in America: Perestroika"
Made professional stage debut in production of "The Importance of Being Earnest" at Seattle's Intiman Theatre
Played Molly Kagan, the ex-wife of a Hollywood studio executive in the USA Network miniseries "The Starter Wife"; earned Emmy, Golden Globe and SAG nominations for Best Actress
Reprised the role of Molly Kagan in the USA Network series "The Starter Wife"; earned a Golden Globe nomination for Best Actress in a Comedy Series in 2009
Co-starred opposite Eric McCormack as roommates on the NBC sitcom "Will & Grace"; earned Emmy (2000, 2001, 2006), Golden Globe (2002, 2003, 2004) and SAG (2004) nominations for Best Actress in a Comedy
Was named Junior Miss Rhode Island in 1986 and competed that year in the national Junior Miss pageant in Mobile, Alabama
Made her Broadway debut in the John Patrick Shanley play "Outside Mullangar" alongside in January 2014; the show was nominated for Best Play in the 2014 Tony Awards.
Starred as Laura Diamond in the NBC show "The Mysteries of Laura"
Reprised breakout role as Grace Adler on "Will & Grace" revival