Moved to New York at age 20 (date approximate)
Appeared off-Broadway in "Kaspar," winning an OBIE and a Drama Desk Award
Feature film debut playing one of the inmates in Milos Forman's "One Flew Over the Cuckoo's Nest" opposite Jack Nicholson
Played Czar Alexander I in the PBS miniseries "The Adams Chronicles"
Acted opposite Meryl Streep in Broadway production of "Happy End"
"Goin' South" reteamed him with Nicholson and De Vito
Starred as 'Reverend Jim' Ignatowski in the classic TV sitcom "Taxi" (ABC); joined as regular cast member in second season; won two Emmy Awards
TV miniseries debut, "The Word" (CBS)
TV movie debut, "Lacy and the Mississippi Queen" (NBC)
Appeared as Phillip Semenka on two-part episode of "Cheers" (NBC)
Played the villain (Jim Ignatowski goes Klingon) in "Star Trek III: The Search for Spock"
Portrayed Professor Plum in "Clue," based on the play inspired by the board game
First collaboration with director Robert Zemeckis and screenwriter Bob Gale, "Back to the Future" as Doc Emmett L. Brown opposite Michael J. Fox's Marty McFly
Teamed with Zemeckis and Gale for the "Go to the Head of the Class" episode of NBC's "Amazing Stories"
Portrayed Judge Doom in Zemeckis' "Who Framed Roger Rabbit"
Reprised Doc Brown in "Back to the Future II"
Returned to the loony bin as self-serious tidiness freak of "The Dream Team"
Returned as Brown for "Back to the Future III"
Provided the voice of Dr. Emmett Brown and appeared in live-action intros and epilogues for the animated series "Back to the Future" (CBS): reprised the character for the Universal Studios' theme park attraction "Back to the Future...The Ride"
Played Uncle Fester in "The Addams Family," a featured based on the 1960s ABC series
Won his third Emmy for guest appearance on Disney's "Avonlea"
Won an Independent Spirit Award for his outstanding supporting portrayal of a well-spoken, purposeful stick-up man in "Twenty Bucks"; Endre Bohem wrote the original screenplay in 1935, and his son Leslie rewrote it and saw it into production
Reprised Uncle Fester for "Addams Family Values"
Portrayed Al the Angel for "Angels in the Outfield"
Played Pieces, a porno projectionist with leprosy whose toes and other parts are falling off in "Things to Do in Denver When You're Dead"
Acted in the first interactive film "Mr. Payback"; directed by Bob Gale
Landed role as the villainous Sebastian Jackal on UPN's "Deadly Games," executive produced by Leonard Nimoy
Made his CD-ROM game debut in the interactive "Toonstruck," reprising his Judge Doom character from "Who Framed Roger Rabbit"
Executive produced Tiffanie DeBartolo's feature directing debut "Dream for an Insomniac"
Provided voice of Rasputin for animated feature "Anastasia"
Reprised Al for "The Wonderful World of Disney" (ABC) presentation of "Angels in the Endzone"
Starred in Bob Clark's "The Ransom of Red Chief," a "Wonderful World of Disney" remake of the O. Henry story
Acted in the off-Broadway revival of "Waiting for Godot"
Reteamed with Michael J. Fox for the "Back to the Future IV: Judgment Day" episode of the ABC sitcom "Spin City"
Portrayed Uncle Martin in "My Favorite Martian," the feature version of the 1960s CBS sitcom
Played the White Knight in the NBC movie adaptation of "Alice in Wonderland"
Reteamed with Clark for "Baby Geniuses" opposite Kathleen Turner
Appeared as himself in Milos Forman's "Man on the Moon," the biopic of Lloyd's "Taxi" cohort Andy Kaufman
Played supporting role in the HBO adaptation of "Wit"
Starred opposite Holland Taylor in a Los Angeles production of Yasmina Reza's play "The Unexpected Man"
Cast in the Fox series "Stacked" opposite Pamela Anderson
Cast in Showtime's "Masters of Horror" anthology series
Voiced the character of Hovis in the animated fantasy film "The Tale of Despereaux"
Acted opposite Elisabeth Shue in the action thriller "Piranha 3D"
Cast as The Wizard of Oz in the Syfy miniseries "The Witches of Oz"
Returned for the thriller sequel "Piranha 3DD"