Cast in Wim Wenders' neo-Western "Don't Come Knocking," written by and starring Sam Shepard
Joined an ensemble cast for the feature "Masked and Anonymous"
Made London stage debut as Blanche in "A Streetcar Named Desire"
Reprised Blanche DuBois for small screen adaptation of "A Streetcar Named Desire" (CBS)
Starred opposite De Niro in "Night and the City"
Tackled first Shakespearean role as Tamora opposite Anthony Hopkins in "Titus," Julie Taymor's feature directorial debut
Delivered a sizzle turn as the unfaithful wife Cora opposite Jack Nicholson in the remake of "The Postman Always Rings Twice"
Played wife to Liam Neeson's "Rob Roy"
Portrayed Edith Ewing Bouvier 'Big Edie,' opposite Drew Barrymore as 'Little Edie,' in HBO "Grey Gardens"; earned Golden Globe and SAG nominations for Best Actress in a TV Movie
Received a Best Actress Academy Award nomination for her portrayal of country singer Patsy Cline in "Sweet Dreams"
Teamed with Nick Nolte and Robert De Niro for Martin Scorsese's remake of "Cape Fear"
Cast as an ex-flame of Bill Murray's in Jim Jarmusch's "Broken Flowers"
Co-starred with Joan Allen and Kathy Bates in the drama "Bonneville"
Played title role in film version of Balzac's "Cousin Bette"
Played lead role of Alexandra Bergson in the CBS adaptation of Willa Cather's "O Pioneers!"
Played wife to Albert Finney in "Big Fish"
Signed seven-year contract with Dino De Laurentiis
Theater debut in summer stock production of "Angel on My Shoulder" in North Carolina
TV acting debut as Maggie in the Showtime production of Tennessee Williams' "Cat on a Hot Tin Roof"
Broadway debut as Blanche DuBois in "A Streetcar Named Desire"
Co-starred in the HBO movie "Normal"; received Emmy and Golden Globe nominations for Best Actress in a Television Movie
First film as co-producer, "Country"; earned second Best Actress Oscar nomination
Portrayed the heroine's mother in the film version of "Prozac Nation"
Starred in "Far North"; directed by off-screen companion Sam Shepard
Co-starred with Dylan McDermott and Connie Britton on FX thriller "American Horror Story"
Featured opposite Rachel McAdams and Channing Tatum in romantic drama "The Vow"
Appeared in the thriller "In Secret"
Became first actress since 1942 to be nominated for two Oscars in the same year; nominated for Best Actress for "Frances" and Best Supporting Actress for "Tootsie"; won the latter award
Returned to the London stage to star as Mary Tyrone in "Long Day's Journey Into Night"
Cast as the Angel of Death in Bob Fosse's autobiographical "All That Jazz"
Won second Oscar as Best Actress for her performance in "Blue Sky"
Garnered a Best Actress Oscar nod for her performance as a lawyer defending her father against charges he was a Nazi collaborator in "The Music Box"
Portrayed Amanda Wingfield in Tennessee Williams' "The Glass Menagerie" on Broadway
Made her film debut in "King Kong"
Cast in lead role as Sister Mary Jude on "American Horror Story: Asylum" (FX)
Played Joan Crawford on the series "Feud"