Made stage debut in "The Verdict" in Meridian, MS
"Discovered" by John Carradine while performing at the Galley Circle Theatre in New Orleans, LA
Cast by Carradine in his San Francisco production of "Tobacco Road"
Worked as a model and as a Copacabana nightclub dancer
Early TV credit, a guest appearance on the syndicated "Big Story"
Appeared in touring production of "A Hatful of Rain"
Off-Broadway debut, "Orpheus Descending," a play written by her cousin Tennessee Williams ; met her future first husband, actor Bruce Dern
Toured in revue "Medium Rare"
Made film debut in "Something Wild"
Played first major film role in Roger Corman's biker pic "The Wild Angels" (with husband Dern)
Made Broadway debut in "Carry Me Back to Morningside Heights," co-starring with Louis Gossett Jr. and Cicely Tyson
Reteamed with Dern for another biker pic "Rebel Rousers"
Appeared with Robert De Niro in Shelley Winters' play "One Night Stands of a Noisy Passenger"
Joined the cast of CBS soap opera "The Secret Storm"
TV-movie debut, "The Devil's Daughter" (ABC)
Played Ida Sessions in Roman Polanski's "Chinatown"
Delivered breakthrough film role, the tough-talking waitress Flo in "Alice Doesn't Live Here Anymore"; earned first Oscar nomination as Best Supporting Actress
Starred on Broadway as Lu Ann Hampton Laverty Oberlander in Preston Jones' "A Texas Trilogy"
Co-starred as Belle Dupree on the CBS sitcom "Alice", based on the film "Alice Doesn't Live Here Anymore"
Portrayed Margaret Kelly, mother of the actress in the ABC biopic "Grace Kelly"
Gained 24 pounds to play character 15 years her senior in Martha Coolidge's pleasant teen flick "Plain Clothes"
Played the insane, obsessive mother of Lula (played by real-life daughter Laura Dern) in David Lynch's "Wild at Heart"; garnered second Best Supporting Actress Academy Award nomination
Co-starred with daughter Laura Dern in Coolidge's "Rambling Rose"; became first mother-daughter team to win Oscar nominations (Dern, Best Actress; Ladd, Best Supporting Actor) in the same year for the same film
Starred opposite Mark Harmon in "Hallmark Hall of Fame" remake of "Shadow of a Doubt" (CBS), originally directed by Alfred Hitchcock
Guest starred on "Dr. Quinn, Medicine Woman" (CBS)
Acted in daughter Laura Dern's directorial debut "The Gift" that aired on Showtime's "Directed By" series
Appeared alongside daughter in CBS miniseries "Ruby Ridge: An American Tragedy," directed by Roger Young
Film directing debut, "Mrs. Munck" (Showtime); also scripted; featured ex-husband Bruce Dern; daughter Laura made a behind-the-scenes documentary titled "Mom and Dad's Movie," which aired on Showtime following the picture
Played mother to Laura Dern's character in "Citizen Ruth"
Portrayed Mamma Stanton (mother of Clintonesque presidential candidate played by John Travolta) in Mike Nichols' "Primary Colors"
Appeared in Betty Thomas' "28 Days"
Acted with daughter and Laura's then-boyfriend Billy Bob Thornton in Thornton's "Daddy and Them"; screened at Montreal
Landed featured role in "Rain"; film screened at Sundance
Co-starred with Ashley Judd in Joey Lauren Adams' screenwriting and directing debut "Come Early Morning"
Appeared in David Lynch's "Inland Empire," starring her daughter Laura Dern and Jeremy Irons
Released the book <i>Spiraling Through the School of Life: A Mental, Physical, and Spiritual Discovery</i>
Received star on the Hollywood Walk of Fame along with ex-husband Bruce and daughter Laura
Returned to series TV with supporting role opposite daughter Laura on HBO's "Enlightened"